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Tetanus-Diphtheria-Pertussis Vaccine Resource Center


Diphtheria Diphtheria is an acute and infectious illness caused by the bacteria Corynebacterium diphtheria, which spreads from person to person usually through respiratory droplets. It is characterized by a grayish, thick covering that sticks to the back of the throat or nasal mucosa and can obstruct the airway. Diphtheria is rare in the U.S. since the introduction of the vaccine in 1920s. It remains a concern for inadequately vaccinated people who are traveling in or exposed to infected persons from underdeveloped countries.  

Source: Centers for Disease Control and Prevention


PertussisPertussis (or whooping cough) is a highly contagious respiratory infection caused by the bacteria Bordetella pertussis, and spreads from person to person through large respiratory droplets generated by coughing or sneezing. 

Pertussis is characterized by an uncontrollable violent cough that can last for up to 10 weeks. It is common in the United States, with a recent peak in 2012. Infants and young children are at greater risk for complications.

Source: Centers for Disease Control and Prevention



Tetanus (or lockjaw) is a serious but not contagious disease. Spores of the bacteria, Clostridium tetani, are found in soil, dust, and animal feces. When these spores enter the body through a wound, they produce a toxin that impairs the nerves controlling the muscles. 

Generalized tetanus typically presents with lockjaw, muscle stiffness and painful body spasms. The fatality rate is approximately 18 percent.

Source: Centers for Disease Control and Prevention

DTaP vaccines are licensed for use among infants in the United States, and are given in a 5-dose series at 2, 4, 6, and 15-18 months, and 4-6 years. DTaP vaccines are often combined with others, such as Hib, Hepatitis B, polio and pneumococcal vaccines. Some are only licensed for the first four doses of the pediatric series.

To reduce the likelihood of transmission of pertussis, a single Tdap dose is recommended for persons aged 11 through 18 years who have completed the childhood series, and for all adults 19 and older, regardless of the interval since the last dose of Td was administered. 

Women are also recommended to receive one dose of Tdap vaccine for each pregnancy, optimally during the third trimester, to provide some protection to the newborn through passive immunity until they can be immunized themselves at age 2 months.

Resource Center

You will find below all of the resources you will need about the tetanus-diphtheria-pertussis vaccine. More will be added as they are published or released.

Information Paper Date
Tetanus, Diphtheria and Pertussis Diseases and Vaccines April 26, 2019
Standing Orders Date
Diphtheria, Tetanus and Acellular Pertussis (DTaP) Vaccine (Pediatric)
June 2022
Tetanus, Diphtheria and Pertussis (Tdap-Td) Vaccines (Pediatric)
June 2022
Tetanus, Diphtheria and Pertussis (Tdap-Td) Vaccines (Adult)
June 2022
Vaccine Information Statements (VIS) Date
Td Vaccine: What You Need to Know
Aug. 6, 2021
Tdap Vaccine: What You Need to Know
Aug. 6, 2021
DTaP Vaccine: What You Need to Know
Aug. 6, 2021
Your Child’s First Vaccines: What You Need to Know
Oct. 15, 2021
Manufacturer Package Inserts Date
May 11, 2023
Nov. 23, 2022
July 21, 2022
Diphtheria and Tetanus Toxoid Adsorbed
Dec. 20, 2018
Nov. 23, 2022
Nov. 23, 2022
April 26, 2023
Oct. 21, 2022
July 21, 2022
Dec. 16, 2022
April 12, 2023
Advisory Committee on Immunization Practices (ACIP) Recommendations Date
DTaP/Tdap/Td Vaccines
Jan. 24, 2020

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Tetanus, Diphtheria and Pertussis Diseases and Vaccines

Fact Sheet

This information paper describes tetanus, diphtheria and pertussis diseases, and the vaccines to prevent them.

Imported Toxin-Producing Cutaneous Diphtheria — Minnesota, Washington, and New Mexico, 2015–2018


Four confirmed cases of cutaneous diphtheria occurred in the U.S., where it is extremely rare. All four subjects had recently traveled internationally to countries with endemic diphtheria. Diptheria toxoid-containing vaccine was provided to incompletely immunized patients and close contacts.

Global Routine Vaccination Coverage — 2017


Global coverage with vaccines to prevent diphtheria, tetanus, pertussis, polio, and measles has remained at 84%–85% since 2010. Prioritizing countries with the highest number of unvaccinated children to implement context-specific strategies has the potential to increase immunization coverage globally.

Barriers to Receipt of Prenatal Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Among Mothers of Infants Aged <4 Months with Pertussis — California, 2016


Among 66 interviewed mothers of infants aged <4 months with pertussis, 30% appropriately received Tdap vaccine. Women whose clinics stocked Tdap vaccine were more likely to be vaccinated.

Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Recommendations of the Advisory Committee on Immunization Practices (ACIP)


This report compiles and summarizes all previously published recommendations from CDC’s Advisory Committee on Immunization Practices (ACIP) regarding prevention and control of tetanus, diphtheria, and pertussis in the United States.

Tdap Vaccination Coverage During Pregnancy — Selected Sites, United States, 2006–2015


Among the pregnant women participating in the study, Tdap vaccination coverage increased from <1% before 2010 to 28% in 2013, and reached 53% in 2015.

Vaccination Coverage for Selected Vaccines, Exemption Rates, and Provisional Enrollment Among Children in Kindergarten — United States, 2016–17 School Year


This report summarizes 2016–17 school year MMR, DTaP, and varicella vaccination coverage reported by immunization programs in 49 states.

Immunization Recommendations for Disaster Response Operations

Fact Sheet

This information paper provides immunization recommendations and resources for Department of Defense (DOD) personnel supporting disaster response operations, both in CONUS and OCONUS.

Notes from the Field: Obstetric Tetanus in an Unvaccinated Woman After a Home Birth Delivery — Kentucky, 2016


BUMED Recommendations for use of Tdap Vaccine in Healthcare Providers


Recommendations for use of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine in Healthcare Providers

Use of Tdap Vaccine


Use of Tetanus Toxiod, Reduced Diptheria Toxoid, and Acellular Pertussis (Tdap) Vaccine

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Last Updated: May 23, 2023
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