Back to Top Skip to main content

World AIDS Day puts spotlight on landmark DoD study

Dr. John Mascola, director of the National Institutes of Health Vaccine Research Center, discusses HIV vaccine progress at the Walter Reed Army Institute of Research, Nov. 26, during a World AIDS Day commemoration.  (U.S. Army photo) Dr. John Mascola, director of the National Institutes of Health Vaccine Research Center, discusses HIV vaccine progress at the Walter Reed Army Institute of Research, Nov. 26, during a World AIDS Day commemoration. (U.S. Army photo)

Recommended Content:

Immunization Healthcare | Research and Innovation | Global Health Engagement

The Walter Reed Army Institute of Research (WRAIR) hosted a World AIDS Day event Tuesday, Nov. 26, highlighting advances in DoD-led HIV research and celebrating the 10th anniversary of the Army-led RV144 HIV vaccine study.

WRAIR’s Military HIV Research Program or MHRP headed the RV144 study, the first-ever – and only to-date – clinical trial to demonstrate that an HIV vaccine regimen was safe and modestly effective in preventing HIV infection. The study sought to determine what methods could be used to lower risk of contracting the disease.

The RV144 trial represented a massive undertaking for the Army and serves as a model of international and interagency collaboration. It involved more than 16,000 adult volunteers and a large network of partners who still work with WRAIR today, including the Thai Ministry of Public Health; the National Institute of Allergy and Infectious Diseases – part of the National Institutes of Health; and Sanofi Pasteur.

In 2009, the Army announced that the study’s investigational prime-boost vaccine regimen lowered the rate of HIV infection by 31.2 percent. These results, although modest, gave the global community hope that a vaccine to prevent HIV infection is possible at a time when such an achievement seemed elusive.

“RV144 was the light at the time in the field, without which we may have given up,” said Dr. John Mascola, director of the National Institutes of Health Vaccine Research Center and the featured speaker at WRAIR’s World AIDS Day event. “In the last 10 years of HIV vaccine progress, RV144 is the anchor.”

The landmark trial continues to provide scientific direction to help guide vaccine development and testing. RV144 and its follow-on trials allowed researchers to discover of risk factors, provide targets for optimizing vaccine boosting, and form a foundation for three HIV vaccine candidates currently undergoing efficacy testing. A video featuring many prominent HIV researchers who were involved with RV144 was shown at the World AIDS Day event.

Also at the event, Lt. Gen (Ret.) Eric B. Schoomaker, 42nd surgeon general of the United States Army and former commanding general of the United States Army Medical Command, highlighted the military’s earliest contributions to HIV research, which include the development of a disease staging system and promoting the finding that HIV can be transmitted heterosexually. The military’s HIV research efforts were consolidated in 1986 with the establishment of MHRP.

MHRP’s initial mission was to advance an HIV vaccine to protect service members and the global community from HIV, but has since expanded beyond vaccine development to include cure research and prevention and treatment services in Africa under the President’s Emergency Plan for AIDS Relief or PEPFAR. Via PEPFAR initiatives, WRAIR provides life-saving antiretroviral therapy to more than 350,000 people living with HIV in sub-Saharan Africa, which contributes to global health security.

WRAIR supports PEPFAR activities within military and civilian communities in four countries where it conducts research (Nigeria, Tanzania, Uganda, and Kenya), which strengthens community trust and provides an ethical framework for clinical studies. The Department of Defense HIV/AIDS Prevention Program, led by the U.S. Navy, is responsible for assisting foreign military partners with the development and implementation of military-specific HIV/AIDS prevention and treatment programs in more than 55 countries around the globe, also supported by PEPFAR.

“Those countries that partner with us on PEPFAR have a 40-percent decrease in violence and a 40-increase in political stability,” said WRAIR Commander Army Col. Deydre Teyhen. “So we say that soldier health is world health. But in fighting HIV/AIDS, WRAIR researchers are also working to advance world peace.”

More information can be found on the RV144 HIV Trial web page.

You also may be interested in...

Immunization University Certificate Retrieval Instructions

Publication
2/14/2018

This document provides instructions for students to retrieve their certificates for Immunization University courses

Recommended Content:

Immunization Healthcare

U.S. Military HIV Research Program

Fact Sheet
12/8/2017

The U.S. Military HIV Research Program (MHRP) is at the forefront of the battle against HIV to protect U.S. troops from infection and to reduce the global impact of the disease.

Recommended Content:

Global Health Engagement | HIV/AIDS Prevention and Treatment

Increasing Partner-Nation Capacity Through Global Health Engagement

Publication
12/6/2017

GHE operations, activities, and actions (OAA) are used to implement the Secretary of Defense Policy Guidance for DoD GHE and the U.S. Army Medicine 2017 Campaign Plan in direct support of the U.S. Pacific Command (USPACOM) theater campaign plan (TCP) and U.S. Army Pacific (USARPAC) theater campaign support plan.

Recommended Content:

Global Health Engagement | Building Partner Capacity and Interoperability

Trauma Care in Support of Global Military Operations

Publication
12/6/2017

The Department of Defense (DoD) Joint Trauma System (JTS) revolutionized combat casualty care by creating a trauma system for the battlefield.

Recommended Content:

Global Health Engagement | Force Health Protection

AFHSB's health surveillance program supports Defense Department global health engagement efforts

Article
11/30/2017
U.S. Air Force Senior Airman Joshua Douglass, left, an aerospace medical technician, watches as Liberian health care workers properly put on their personal protective equipment as part response by the Defense Department operation to provide logistics, training and engineering support during the Ebola virus outbreak. (U.S. Army photo by Staff Sgt. Terrance D. Rhodes)

Navy Commander Franca R. Jones, chief of the Global Emerging Infections section at the Armed Forces Health Surveillance Branch (AFHSB) discusses how AFHSB's health surveillance program supports the Defense Department global health engagement efforts.

Recommended Content:

Armed Forces Health Surveillance Branch | Global Emerging Infections Surveillance | Antimicrobial Resistance (AMR) Surveillance | Febrile and Vector-Borne Infections (FVBI) Surveillance | Enteric Infections (EI) Surveillance | GEIS Partners | Global Health Engagement | Global Health Engagement

Strengthening capabilities, fostering partnership top priorities at global health summit

Article
10/27/2017
Admiral Tim Ziemer, head of U.S. delegation, giving remarks at the Global Health Security Agenda Ministerial Meeting in Kampala, Uganda.

A growing partnership of more than 60 nations is working to build countries’ capacity to help create a world safe and secure from infectious disease threats and elevate global health security

Recommended Content:

Global Health Engagement | Global Health Security Agenda

National, Regional, State, and Selected Local Area Vaccination Coverage Among Adolescents Aged 13–17 Years — United States, 2016

Report
8/25/2017

CDC provides up-to-date estimated immunization rates among teens using the latest recommended immunization schedules.

Recommended Content:

Immunization Healthcare | Vaccine Schedules | Vaccine-Preventable Diseases

Improving Defense Health Program Medical Research Processes

Report
8/8/2017

A report from the Defense Health Board (DHB) that summarizes the findings and recommendations from its independent review of Improving Defense Health Program (DHP) Medical Research Processes.

Recommended Content:

Research and Innovation | Health Readiness

DoD Instruction 2000.30: Global Health Engagement Activities

Policy

This instruction establishes policy, assigns responsibilities, and prescribes procedures for the conduct of global health engagement activities with partner nation (PN) entities.

DoDEA Immunization Requirements School Year 2017-18

Publication
5/26/2017

Students who enroll in Department of Defense Education Activity (DoDEA) schools are required to meet specific immunization requirements.

Recommended Content:

Immunization Healthcare | Vaccine Schedules

Surveillance of Vaccination Coverage Among Adult Populations — United States, 2015

Report
5/10/2017

The findings provided in this report indicate that vaccination coverage levels among U.S. adults are not optimal. Improvement in adult vaccination is needed to reduce the health consequences of vaccine-preventable diseases among adults.

Recommended Content:

Immunization Healthcare | Vaccine-Preventable Diseases | Vaccine Recommendations

CDC Pink Book Supplement 2017

Publication
2/22/2017

Epidemiology and Prevention of Vaccine-Preventable Diseases - 13th Edition - Supplement

Recommended Content:

Immunization Healthcare

Agenda: February 9, 2017

Meeting Reference
2/9/2017

Agenda for the February 9, 2017 DHB Meeting

Recommended Content:

Research and Innovation | Access, Cost, Quality, and Safety

Minutes: February 9, 2017

Meeting Reference
2/9/2017

Minutes from the DHB meeting on February 9, 2017

Recommended Content:

Research and Innovation

Defense Health Agency Overview

Presentation
2/9/2017

Defense Health Agency Overview

Recommended Content:

Military Medical History | Research and Innovation
<< < ... 6 7 8 9 10  ... > >> 
Showing results 121 - 135 Page 9 of 18

DHA Address: 7700 Arlington Boulevard | Suite 5101 | Falls Church, VA | 22042-5101

Some documents are presented in Portable Document Format (PDF). A PDF reader is required for viewing. Download a PDF Reader or learn more about PDFs.