Back to Top Skip to main content Skip to sub-navigation

World AIDS Day puts spotlight on landmark DoD study

Dr. John Mascola, director of the National Institutes of Health Vaccine Research Center, discusses HIV vaccine progress at the Walter Reed Army Institute of Research, Nov. 26, during a World AIDS Day commemoration.  (U.S. Army photo) Dr. John Mascola, director of the National Institutes of Health Vaccine Research Center, discusses HIV vaccine progress at the Walter Reed Army Institute of Research, Nov. 26, during a World AIDS Day commemoration. (U.S. Army photo)

Recommended Content:

Immunization Healthcare | Research and Innovation | Global Health Engagement

The Walter Reed Army Institute of Research (WRAIR) hosted a World AIDS Day event Tuesday, Nov. 26, highlighting advances in DoD-led HIV research and celebrating the 10th anniversary of the Army-led RV144 HIV vaccine study.

WRAIR’s Military HIV Research Program or MHRP headed the RV144 study, the first-ever – and only to-date – clinical trial to demonstrate that an HIV vaccine regimen was safe and modestly effective in preventing HIV infection. The study sought to determine what methods could be used to lower risk of contracting the disease.

The RV144 trial represented a massive undertaking for the Army and serves as a model of international and interagency collaboration. It involved more than 16,000 adult volunteers and a large network of partners who still work with WRAIR today, including the Thai Ministry of Public Health; the National Institute of Allergy and Infectious Diseases – part of the National Institutes of Health; and Sanofi Pasteur.

In 2009, the Army announced that the study’s investigational prime-boost vaccine regimen lowered the rate of HIV infection by 31.2 percent. These results, although modest, gave the global community hope that a vaccine to prevent HIV infection is possible at a time when such an achievement seemed elusive.

“RV144 was the light at the time in the field, without which we may have given up,” said Dr. John Mascola, director of the National Institutes of Health Vaccine Research Center and the featured speaker at WRAIR’s World AIDS Day event. “In the last 10 years of HIV vaccine progress, RV144 is the anchor.”

The landmark trial continues to provide scientific direction to help guide vaccine development and testing. RV144 and its follow-on trials allowed researchers to discover of risk factors, provide targets for optimizing vaccine boosting, and form a foundation for three HIV vaccine candidates currently undergoing efficacy testing. A video featuring many prominent HIV researchers who were involved with RV144 was shown at the World AIDS Day event.

Also at the event, Lt. Gen (Ret.) Eric B. Schoomaker, 42nd surgeon general of the United States Army and former commanding general of the United States Army Medical Command, highlighted the military’s earliest contributions to HIV research, which include the development of a disease staging system and promoting the finding that HIV can be transmitted heterosexually. The military’s HIV research efforts were consolidated in 1986 with the establishment of MHRP.

MHRP’s initial mission was to advance an HIV vaccine to protect service members and the global community from HIV, but has since expanded beyond vaccine development to include cure research and prevention and treatment services in Africa under the President’s Emergency Plan for AIDS Relief or PEPFAR. Via PEPFAR initiatives, WRAIR provides life-saving antiretroviral therapy to more than 350,000 people living with HIV in sub-Saharan Africa, which contributes to global health security.

WRAIR supports PEPFAR activities within military and civilian communities in four countries where it conducts research (Nigeria, Tanzania, Uganda, and Kenya), which strengthens community trust and provides an ethical framework for clinical studies. The Department of Defense HIV/AIDS Prevention Program, led by the U.S. Navy, is responsible for assisting foreign military partners with the development and implementation of military-specific HIV/AIDS prevention and treatment programs in more than 55 countries around the globe, also supported by PEPFAR.

“Those countries that partner with us on PEPFAR have a 40-percent decrease in violence and a 40-increase in political stability,” said WRAIR Commander Army Col. Deydre Teyhen. “So we say that soldier health is world health. But in fighting HIV/AIDS, WRAIR researchers are also working to advance world peace.”

More information can be found on the RV144 HIV Trial web page.

You also may be interested in...

Checklist: Best Practices for Vaccination Clinics Held at Satellite, Temporary, or Off-Site Locations

Publication
10/20/2021

A step-by-step guide to help clinic supervisors follow Centers for Disease Control and Prevention (CDC) and Department of Defense (DOD) guidelines while overseeing any nontraditional vaccination clinic setting.

Recommended Content:

Immunization Healthcare | Vaccine-Preventable Diseases | Vaccine Storage and Handling

International Partnerships Foster Improvements in Military Health Care

Article
9/23/2021
Dr. Smith presenting at a podium

U.S. Deputy Assistant Secretary of Defense for Health Readiness Policy and Oversight Dr. David Smith spoke about what makes global health, specifically military partnerships, work as part of the ICMM’s "Centennial Talks," in Schelle, Belgium.

Recommended Content:

Global Health Engagement | Dr. David J. Smith | Uniformed Services University of the Health Sciences

Dr. David Smith at "Centennial Talks"

Photo
9/23/2021
Dr. Smith presenting at a podium

U.S. Deputy Assistant Secretary of Defense for Health Readiness Policy and Oversight Dr. David Smith speaks at the International Committee of Military Medicine’s "Centennial Talks," a hybrid in-person and online event broadcast from Schelle, Belgium, Sept. 21 (Screenshot from official livestream of event taken by MHS Communications),

Recommended Content:

Global Health Engagement | Dr. David J. Smith | Uniformed Services University of the Health Sciences

Since 9/11, These 8 Military Medical Advancements are Saving Lives

Article
9/14/2021
Retired U.S. Army Sgt. Derek Weida jokes with a physician during his prosthetic leg fitting at a prosthetics clinic in Las Vegas in April 2018.

Years of military conflict in Iraq and Afghanistan brought innovations that completely transformed the Military Health System's approach to combat casualty care. Here's a list of just a few ways military medicine has evolved in the two decades since the 9/11 attacks.

Recommended Content:

Research and Innovation | Technology | MHS Remembers 9/11 | 20th Anniversary of 9/11: Call-to-Action

Ready Reliable Care Framework is Improving MHS Patient Care

Article
8/18/2021
Ready Reliable Care is the Military Health System's framework for ensuring high-quality health care across the force.

The Military Health System's Ready Reliable Care framework helps ensure high-quality health care for all service members, veterans and their families.

Recommended Content:

Research and Innovation | Technology | Readiness Capabilities | Ready Reliable Care | MHS GENESIS

Don't Hesitate: Vaccinate Today for School

Article
8/13/2021
A boy gets the COVID-19 vaccine

Back to School Means Vaccine Time

Recommended Content:

COVID-19 Vaccine Efforts | Coronavirus | Immunization Healthcare | Vaccine-Preventable Diseases | Vaccine Recommendations | Children's Health | Immunizations | TRICARE Health Program

General Best Practice Guidelines for Immunization

Publication
8/10/2021

The Centers for Disease Control and Prevention (CDC) recommends routine vaccination to prevent 17 vaccine-preventable diseases that occur in infants, children, adolescents, or adults. This report provides information for clinicians and other health care providers about concerns that commonly arise when vaccinating persons of various ages.

Recommended Content:

Immunization Healthcare | Vaccine Recommendations | Continuous Quality Immunization Improvement Process (CQIIP) and Virtual Continuous Quality Immunization Improvement Process (VCQIIP)

MHS and MOS Town Hall To Your Health: Back to School

Article
8/10/2021
Infographic about the To Your Health Town Hall

MHS and Military OneSource presents a summer safety discussion with experts about Back to School Vaccinations and Beyond

Recommended Content:

Immunization Healthcare | Vaccine-Preventable Diseases | Children's Health | MHS and Military OneSource To Your Health

Vaccinations To Your Health

Video
8/9/2021
Infographic about MHS and MOS  Town Hall

Join us live with Defense Health Agency and Board Certified Family Nurse Practitioner, Ann Morse, to discuss vaccines, vaccine safety and tips for keeping your military family healthy as the new school year approaches.

Recommended Content:

Immunization Healthcare | Vaccine-Preventable Diseases | Children's Health | MHS and Military OneSource To Your Health

Revamped Virtual Med Center Makes Health Care Feel Like a Video Game

Article
7/26/2021
Picture of the Virtual Medical Center

The Virtual Medical Center, a joint Department of Defense/VA incentive, is relaunching by the end of summer, leveraging emerging technologies to increase and improve accessibility, convenience, and efficiency of medical care for all registered users.

Recommended Content:

Technology | Research and Innovation

Military Medical Research Leads to 18 New Cancer Drugs, other Devices

Article
7/14/2021
a patient prepares for a PET scan

A hub of cutting-edge healthcare innovation financing since the early 1990s, the CDMRP is well known among medical researchers around the world.

Recommended Content:

Research and Innovation | Medical Research and Development

Military Health System Transformation Will Improve Care & Innovation

Article
7/6/2021
Infographic about Health Innovation Month

MHS Innovation Must Be Backed by Best Practices, Standardization

Recommended Content:

July Toolkit | Health Innovation – Pathways to Ready Reliable Care | Health Innovations across the MHS Enterprise | Health Innovation Month | Research and Innovation | Military Health System Transformation | MHS Research Symposium

DHA Spearheads Effort for Working Dog Research Collaboration

Article
6/25/2021
Picture of three different dogs

Working Dog Forum explored research to keep dogs in top form.

Recommended Content:

Combat Support | Veterinary Service | Public Health | Research and Innovation

Medical Advances Since Gulf War Boil Down to Increased Lives Saved

Article
6/25/2021
Medical personnel training on how to treat a neck wound

Not all medical advances since the first Gulf War are highly technical.

Recommended Content:

Combat Support | Research and Innovation | Health Innovation Month

Immunization Tool Kit 9th Edition

Publication
4/7/2021

A practical reference that facilitates and enhances the global delivery of quality immunization healthcare to Department of Defense (DoD) beneficiaries and employees. The Defense Health Agency Immunization Healthcare Division (DHA-IHD) publishes the Immunization Tool Kit based on national recommendations, evidenced-based, peer-reviewed published medical literature, and clinical practice guidelines.

Recommended Content:

Immunization Healthcare
<< < 1 2 3 4 5  ... > >> 
Showing results 1 - 15 Page 1 of 17

DHA Address: 7700 Arlington Boulevard | Suite 5101 | Falls Church, VA | 22042-5101

Some documents are presented in Portable Document Format (PDF). A PDF reader is required for viewing. Download a PDF Reader or learn more about PDFs.