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Update: Malaria, U.S. Armed Forces, 2020

Spc. Joshua Jones, left, and Pfc. Richard Bower, both preventive medicine specialists, 227th Preventive Medicine Detachment, 62nd Medical Brigade, check an insect trap during a field training exercise on Joint Base Lewis-McChord, June 20. The 227th PMD notionally deployed to Guiria, Venezuela, where a tropical storm caused floods and presented a real world concern for mosquitos, which are known to spawn in stagnant water and cause widespread vector borne illnesses such as malaria, yellow fever and dengue fever.  Photo by Sgt. Sarah Enos 5th Mobile Public Affairs Detachment Spc. Joshua Jones, left, and Pfc. Richard Bower, both preventive medicine specialists, 227th Preventive Medicine Detachment, 62nd Medical Brigade, check an insect trap during a field training exercise on Joint Base Lewis-McChord, June 20. The 227th PMD notionally deployed to Guiria, Venezuela, where a tropical storm caused floods and presented a real world concern for mosquitos, which are known to spawn in stagnant water and cause widespread vector borne illnesses such as malaria, yellow fever and dengue fever.

Photo by Sgt. Sarah Enos
5th Mobile Public Affairs Detachment

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Medical Surveillance Monthly Report

WHAT ARE THE NEW FINDINGS?

The 2020 total of 28 malaria cases among active and reserve component service members was the lowest annual count of cases during the past 10 years. The 2020 proportion of cases (53.6%) due to P. vivax was the highest of the 10-year period.

WHAT IS THE IMPACT ON READINESS AND FORCE HEALTH PROTECTION?

The decrease in total counts of malaria cases during the last decade reflects the reduced numbers of service members exposed to malaria in Afghanistan. The persistent threat from P. falciparum associated with duty in Africa underscores the importance of preventive measures effective against this most dangerous form of malaria.

ABSTRACT

Malaria infection remains an important health threat to U.S. service members who are located in endemic areas because of long-term duty assignments, participation in shorter-term contingency operations, or personal travel. In 2020, a total of 28 service members were diagnosed with or reported to have malaria. This was the lowest number of cases in any given year during the 10-year surveillance period and represents a 15.2% decrease from the 33 cases identified in 2019. The relatively low numbers of cases during 2012–2020 mainly reflect decreases in cases acquired in Afghanistan, a reduction largely due to the progressive withdrawal of U.S. forces from that country. The number of malaria cases caused by Plasmodium falciparum in 2020 (n=8) was the second lowest observed during the surveillance period. The percentage of 2020 cases of malaria caused by Plasmodium vivax (53.6%; n=15) was the highest during any given year of the surveillance period. The remaining 5 malaria cases were labeled as associated with other/unspecified types of malaria (17.9%). Malaria was diagnosed at or reported from 13 different medical facilities in the U.S., Germany, Africa, and Korea. Providers of medical care to military members should be knowledgeable of and vigilant for clinical manifestations of malaria outside of endemic areas.

BACKGROUND

Worldwide, the incidence rate of malaria is estimated to have decreased from 71.1 per 1,000 population at risk in 2010 to 57.5 in 2015 and 56.8 in 2019.1 These decreases represent reductions of 27% and 2%, respectively, and indicate a slowing of the rate of decline since 2015.1 This plateauing of malaria incidence rates is especially apparent in countries that accounted for high proportions of cases globally (e.g., Nigeria, the Democratic Republic of the Congo, India).1 During 2010–2019, malaria-related deaths decreased steadily from 594,000 in 2010 to 453,000 in 2015 and 409,000 in 2019.1

Countries in Africa accounted for about 94% of worldwide malaria cases and malaria-related deaths in 2019.1 Nigeria (27%), the Democratic Republic of the Congo (12%), Uganda (5%), Mozambique (4%), and Niger (3%) accounted for slightly more than half (51%) of all cases globally.1 Most of these cases and deaths were due to mosquito-transmitted Plasmodium falciparum and occurred among children under 5 years of age,1 but Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae can also cause severe disease. 1–3 Globally in 2019, 2.8% of estimated malaria cases were caused by P. vivax; however, over four-fifths of vivax malaria cases occurred in 6 countries: India, Pakistan, Afghanistan, Ethiopia, Papua New Guinea, and Indonesia.1 It is important to note that, while heightened malaria-control efforts have reduced the incidence of P. falciparum malaria in many areas, the proportion of malaria cases caused by P. vivax has increased in some regions where both parasites coexist (e.g., Djibouti, Pakistan, Venezuela).3,4 

Since 1999, the MSMR has published regular updates on the incidence of malaria among U.S. service members.5–7 The MSMR’s focus on malaria reflects both historical lessons learned about this mosquito borne disease and the continuing threat that it poses to military operations and service members’ health. Malaria infected many thousands of service members during World War II (approximately 695,000 cases), the Korean War (approximately 390,000 cases), and the conflict in Vietnam (approximately 50,000 cases).8,9 More recent military engagements in Africa, Asia, Southwest Asia, the Caribbean, and the Middle East have necessitated heightened vigilance, preventive measures, and treatment of cases.10–19 

In the planning for overseas military operations, the geography-based presence or absence of the malaria threat is usually known and can be anticipated. However, when preventive countermeasures are needed, their effective implementation is multifaceted and depends on the provision of protective equipment and supplies, individuals’ understanding of the threat as well as attention to personal protective measures, treatment of malaria cases, and medical surveillance. The U.S. Armed Forces have long had policies and prescribed countermeasures effective against vector borne diseases such as malaria, including chemoprophylactic drugs, permethrinimpregnated uniforms and bed nets, and topical insect repellents containing N,Ndiethyl-meta-toluamide (DEET). When cases and outbreaks of malaria have occurred, they generally have been due to poor adherence to chemoprophylaxis and other personal preventive measures.11–14

MSMR malaria updates from the past 8 years documented that the annual case counts among service members after 2011 were the lowest in more than a decade.7,20–25 In particular, these updates showed that the numbers of cases associated with service in Afghanistan had decreased substantially in the past 8 years, presumably because of the dramatic reduction in the numbers of service members serving there. This update for 2020 uses methods similar to those employed in previous analyses to describe the epidemiologic patterns of malaria incidence among service members in the active and reserve components of the U.S. Armed Forces.

METHODS

The surveillance period was 1 January 2011 through 31 December 2020. The surveillance population included Army, Navy, Air Force, and Marine Corps active and reserve component members of the U.S. Armed Forces. The records of the Defense Medical Surveillance System (DMSS) were searched to identify reportable medical events and hospitalizations (in military and non-military facilities) that included diagnoses of malaria. A case of malaria was defined as an individual with 1) a reportable medical event record of confirmed malaria; 2) a hospitalization record with a primary diagnosis of malaria; 3) a hospitalization record with a nonprimary diagnosis of malaria due to a specific Plasmodium species; 4) a hospitalization record with a nonprimary diagnosis of malaria plus a diagnosis of anemia, or thrombocytopenia and related conditions, or malaria complicating pregnancy in any diagnostic position; 5) a hospitalization record with a nonprimary diagnosis of malaria plus diagnoses of signs or symptoms consistent with malaria in each diagnostic position antecedent to malaria;26 or 6) a positive malaria antigen test plus an outpatient record with a diagnosis of malaria in any diagnostic position within 30 days of the specimen collection date. The relevant International Classification of Diseases, 9th and 10th Revision (ICD-9 and ICD-10, respectively) codes are shown in Table 1. Laboratory data for malaria were provided by the Navy and Marine Corps Public Health Center.

This analysis allowed 1 episode of malaria per service member per 365-day period. When multiple records documented a single episode, the date of the earliest encounter was considered the date of clinical onset, and the most specific diagnosis recorded within 30 days of the incident diagnosis was used to classify the Plasmodium species. 

Presumed locations of malaria acquisition were estimated using a hierarchical algorithm: 1) cases diagnosed in a malarious country were considered acquired in that country, 2) reportable medical events that listed exposures to malaria-endemic locations were considered acquired in those locations, 3) reportable medical events that did not list exposures to malaria-endemic locations but were reported from installations in malaria-endemic locations were considered acquired in those locations, 4) cases diagnosed among service members during or within 30 days of deployment or assignment to a malarious country were considered acquired in that country, and 5) cases diagnosed among service members who had been deployed or assigned to a malarious country within 2 years before diagnosis were considered acquired in those respective countries. All remaining cases were considered to have acquired malaria in unknown locations.
 

RESULTS

In 2020, a total of 28 service members were diagnosed with or reported to have malaria (Table 2).This total was the lowest number of cases in any given year during the surveillance period and represents a 15.2% decrease from the 33 cases identified in 2019 (Figure 1). The percentage of 2020 cases of malaria caused by P. vivax (53.6%; n=15) was the highest during any given year of the surveillance period. Of the 13 cases in 2020 not attributed to P. vivax, 8 (28.6%) were identified as due to P. falciparum and 5 were reported as associated with other/unspecified types of malaria (17.9%). The number of malaria cases caused by P. falciparum in 2020 was the second lowest observed during the 10-year surveillance period (Figure 1). Similar to 2019, the majority of U.S. military members diagnosed with malaria in 2020 were male (89.3%), active component members (78.6%), in the Army (60.7%), and in their 20s (53.5%) (Table 2).

Of the 28 malaria cases in 2020, slightly more than one-fifth of the infections were considered to have been acquired in Afghanistan (21.4%, n=6); slightly more than one-sixth (17.9%, n=5) were attributed to Africa; and one-seventh (14.3%; n=4) were attributed to Korea (Figure 2). The remaining cases could not be associated with a known, specific location (46.4%, n=13); no cases were considered to have been acquired in South/Central America. Of the 5 malaria infections considered acquired in Africa in 2020, 2 were linked to Djibouti; and 1 each to Benin, Niger, and Burkina Faso (data not shown).

During 2020, malaria cases were diagnosed or reported from 13 different medical facilities in the U.S., Germany, Africa, and Korea (Table 3). Almost three-eighths (36.4%; 8/22) of the total cases with a known location of diagnosis were reported from or diagnosed outside the U.S., which represents a slight increase from the 31.4% of malaria cases in this category in 2019. The largest number of malaria cases associated with a single medical facility during 2020 was 5 at the Landstuhl Regional Medical Center in Germany.

In 2020, the percentage of malaria cases acquired in Africa (17.9%; n=5) decreased from 2019 (45.5%) and was most similar to the percentages in 2011 (19.0%) and 2012 (17.5%) (Figure 2). The percentage of Afghanistan-acquired cases (21.4%; n=6) in 2020 was lower than the percentages in 2019 (30.3%) and 2018 (33.9%). The percentage of malaria cases acquired in Korea (14.3%; n=4) in 2020 was higher than in 2019 (6.1%) and was most similar to the percentages in 2018 (15.3%) and 2017 (14.3%) (Figure 2).

Between 2011 and 2020, the majority of malaria cases were diagnosed or reported during the 6 months from the middle of spring through the middle of autumn in the Northern Hemisphere (Figure 3). In 2020, 57.1% (16/28) of malaria cases among U.S. service members were diagnosed during May–October (data not shown). This proportion is lower than the 74.8% (380/508) of cases diagnosed during the same 6-month intervals over the entire 10-year surveillance period. During 2011–2020, the proportions of malaria cases diagnosed or reported during May–October varied by region of acquisition: Korea (90.3%; 56/62); Afghanistan (83.4%; 161/193); Africa (63.9%; 101/158); and South/Central America (40.0%; 2/5) (data not shown).

EDITORIAL COMMENT

MSMR annual reports on malaria incidence among all U.S. services began in 2007. The current report documents that the number of cases during 2020 decreased from 2019 and was the lowest of any of the previous years in the 2011–2020 surveillance period. Most of the marked decline in the past 9 years is attributable to the decrease in numbers of malaria cases associated with service in Afghanistan. The dominant factor in that trend has undoubtedly been the progressive withdrawal of U.S. forces from that country.

This report also documents the fluctuating incidence of acquisition of malaria in Africa and Korea among U.S. military members during the past decade. The 2020 percentage of cases caused by P. vivax (53.6%) was the highest of any year of the surveillance period. Although the predominant species of malaria in Korea and Afghanistan has been P. vivax, the more dangerous P. falciparum species is of primary concern in Africa. The planning and execution of military operations on the African continent must incorporate actions to counter the threat of infection by that potentially deadly parasite wherever it is endemic. The 2014–2015 employment of U.S. service members to aid in the response to the Ebola virus outbreak in West Africa is an example of an operation where the risk of P. falciparum malaria was significant.19,27 The finding that P. falciparum malaria was diagnosed in more than one-quarter of the cases in 2020 further underscores the need for continued emphasis on prevention of this disease, given its potential severity and risk of death. Moreover, a recent article noted the possibility of false negative results for P. falciparum on the rapid diagnostic tests favored by units in resource-limited or austere locations. 28 Although additional research is needed, commanders and unit leaders may need to be extra vigilant with forces that are far forward. 

The observations about the seasonality of diagnoses of malaria are compatible with the presumption that the risk of acquiring and developing symptoms of malaria in a temperate climatic zone of the Northern Hemisphere would be greatest during May–October. Given the typical incubation periods of malaria infection (approximately 9–14 days for P. falciparum, 12–18 days for P. vivax and P. ovale, and 18–40 days for P. malariae)26 and the seasonal disappearance of biting mosquitoes during the winter, most malaria acquired in Korea and Afghanistan would be expected to cause symptoms during the warmer months of the year. However, it should be noted that studies of P. vivax malaria in Korea have found that the time between primary infection and clinical illness among different P. vivax strains ranges between 8 days and 8–13 months and that as many as 40–50% of infected individuals may not manifest the symptoms of their primary illness until 6–11 months after infection.29,30 Klein and colleagues reported a cluster of 11 U.S. soldiers with P. vivax malaria who were likely infected at a training area located near the southern border of the demilitarized zone in 2015.31 Nine of the malaria cases were identified when patients first presented with symptoms of infection 9 or more months after exposure and after their departure from Korea.31 Transmission of malaria in tropical regions such as sub-Saharan Africa is less subject to the limitations of the seasons as in temperate climates but depends more on other factors affecting mosquito breeding such as the timing of the rainy season and altitude (below 2,000 meters).32

There are significant limitations to this report that should be considered when interpreting the findings. For example, the ascertainment of malaria cases is likely incomplete; some cases treated in deployed or non-U.S. military medical facilities may not have been reported or otherwise ascertained at the time of this analysis. Furthermore, it should be noted that medical data from sites that were using the new electronic health record for the Military Health System, MHS GENESIS, between July 2017 and October 2019 are not available in the DMSS. These sites include Naval Hospital Oak Harbor, Naval Hospital Bremerton, Air Force Medical Services Fairchild, and Madigan Army Medical Center. Therefore, medical encounter data for individuals seeking care at any of these facilities from July 2017 through October 2019 were not included in the current analysis.

Diagnoses of malaria that were documented only in outpatient settings without records of a positive malaria antigen test and that were not reported as notifiable events were not included as cases. Also, the locations of infection acquisitions were estimated from reported relevant information. Some cases had reported exposures in multiple malarious areas, and others had no relevant exposure information. Personal travel to or military activities in malaria endemic countries were not accounted for unless specified in notifiable event reports.

As in prior years, in 2020 most malaria cases among U.S. military members were treated at medical facilities remote from malaria endemic areas. Providers of acute medical care to service members (in both garrison and deployed settings) should be knowledgeable of and vigilant for the early clinical manifestations of malaria among service members who are or were recently in malaria-endemic areas. Care providers should also be capable of diagnosing malaria (or have access to a clinical laboratory that is proficient in malaria diagnosis) and initiating treatment (particularly when P. falciparum malaria is clinically suspected).

Continued emphasis on adherence to standard malaria prevention protocols is warranted for all military members at risk of malaria. Personal protective measures against malaria include the proper wear of permethrin-treated uniforms and the use of permethrin-treated bed nets; the topical use of military-issued, DEET-containing insect repellent; and compliance with prescribed chemoprophylactic drugs before, during, and after times of exposure in malarious areas. Current Department of Defense guidance about medications for prophylaxis of malaria summarizes the roles of chloroquine, atovaquone-proguanil, doxycycline, mefloquine, primaquine, and tafenoquine.33,34

Acknowledgements: The authors thank the Navy Marine Corps Public Health Center, Portsmouth, VA, for providing laboratory data for this analysis.

REFERENCES

1.  World Health Organization. World Malaria Report 2020. WHO, Geneva 2020. Accessed 10 February 2021. https://www.who.int/publications/i/item/9789240015791

2.  Mace KE, Arguin PM, Lucci NW, Tan KR.  Surveillance—United States, 2016. MMWR Surveill Summ. 2019;68(5):1–35. 

3.  Price RN, Commons RJ, Battle KE, Thriemer K, Mendis K. Plasmodium vivax in the era of the shrinking P. falciparum map. Trends Parasitol. 2020;36(6):560–570.

4.  Battle KE, Lucas TC, Nguyen M, et al. Mapping the global endemicity and clinical burden of Plasmodium vivax, 2000–17: a spatial and temporal modelling study. Lancet. 2019;394(10195):332–343. 

5.  U.S. Army Center for Health Promotion and Preventive Medicine. Malaria, U.S. Army, 1998. MSMR. 1999;5(1):2–3.

6.  U.S. Army Center for Health Promotion and Preventive Medicine. Malaria experience among U.S. active duty soldiers, 1997-1999. MSMR. 1999;5(8):2–3.

7.  Armed Forces Health Surveillance Branch. Update: Malaria, U.S. Armed Forces, 2019. MSMR. 2020;27(2):2–7.

8.  Gupta RK, Gambel JM, Schiefer BA. Personal protection measures against arthropods. In: Kelley PW, ed. Military Preventive Medicine: Mobilization and Deployment, Volume 1. Falls Church, VA: Office of the Surgeon General, Department of the Army; 2003:503–521.

9.  Ognibene AJ, Barrett O. Malaria: introduction and background. In: Ognibene AJ, Barrett O, eds. Internal Medicine in Vietnam Vol II: General Medicine and Infectious Diseases. Washington, DC: Office of the Surgeon General, Center of Military History; 1982: 271–278.

10.  Shanks GD, Karwacki JJ. Malaria as a military factor in Southeast Asia. Mil Med.1991; 156(12):684–668.

11.  Kotwal RS, Wenzel RB, Sterling RA, et al. An outbreak of malaria in U.S. Army Rangers returning from Afghanistan. JAMA. 2005;293(2):212–216.

12.  Whitman TJ, Coyne PE, Magill AJ, et al. An outbreak of Plasmodium falciparum malaria in U.S. Marines deployed to Liberia. Am J Trop Med Hyg. 2010;83(2):258–265.

13.  Centers for Disease Control and Prevention. Malaria acquired in Haiti–2010. MMWR. 2010;59(8):217–218.

14.  Shaha DP, Pacha LA, Garges EC, Scoville SL, Mancuso JD. Confirmed malaria cases among active component U.S. Army personnel, January–September 2012. MSMR 2013;20(1):6–9.

15.  Lee JS, Lee WJ, Cho SH, Ree H. Outbreak of vivax malaria in areas adjacent to the demilitarized zone, South Korea, 1998. Am J Trop Med Hyg. 2002;66(1):13–17.

16.  Armed Forces Health Surveillance Center (Provisional). Korea-acquired malaria, U.S. Armed Forces, January 1998–October 2007. MSMR. 2007;14(8):2–5.

17.  Ciminera P, Brundage J. Malaria in U.S. military forces: a description of deployment exposures from 2003 through 2005. Am J Trop Med Hyg. 2007;76(2):275–279.

18.  Armed Forces Health Surveillance Center. Surveillance snapshot: Malaria among deployers to Haiti, U.S. Armed Forces, 13 January–30 June 2010. MSMR. 2010;17(8):11.

19.  Woods M. Biggest threat to U.S. troops in Liberia is malaria, not Ebola. Published 4 December 2014. Accessed 29 January 2021. https://www.army.mil/article/139340/biggest_threat_to_us_troops_in_liberia_is_malaria_not_ebola

20.  Armed Forces Health Surveillance Center. Update: Malaria, U.S. Armed Forces, 2012. MSMR. 2013;20(1):2–5.

21.  Armed Forces Health Surveillance Center. Update: Malaria, U.S. Armed Forces, 2013. MSMR. 2014;21(1):4–7.

22.  Armed Forces Health Surveillance Center. Update: Malaria, U.S. Armed Forces, 2014. MSMR. 2015;22(1):2–6.

23.  Armed Forces Health Surveillance Branch. Update: Malaria, U.S. Armed Forces, 2015. MSMR. 2016;23(1):2–6.

24.  Armed Forces Health Surveillance Branch. Update: Malaria, U.S. Armed Forces, 2016. MSMR. 2017;24(1):2–6.

25.  Armed Forces Health Surveillance Branch. Update: Malaria, U.S. Armed Forces, 2017. MSMR. 2018;25(2):2–7.

26.  Armed Forces Health Surveillance Branch. Surveillance Case Definition: Malaria. February 2019. Accessed 29 January 2021. https://cms.health. mil//Reference-Center/Publications/2014/12/01/Malaria.

27.  Mace KE, Arguin PM, Tan KR. Malaria Surveillance—United States, 2016. MMWR Surveill Summ. 2018;67(7):1–28.

28.  Forshey BM, Morton L, Martin N, et al. Plasmodium falciparum rapid test failures threaten diagnosis and treatment of U.S. military personnel Mil Med. 2020;185(1–2):e1–e4

29.  White, NJ. Determinants of relapse periodicity in Plasmodium vivax malaria. Malar J. 2011 (10):297

30.  Distelhorst JT, Marcum RE, Klein TA, Kim HC, Lee WJ. Report of two cases of vivax malaria in U.S. soldiers and a review of malaria in the Republic of Korea. MSMR. 2014;21(1):8–14.

31.  Klein TA, Seyoum B, Forshey BM, et al. Cluster of vivax malaria in U.S. soldiers training near the demilitarized zone, Republic of Korea during 2015. MSMR. 2018;25(11):4–9.

32.  Fairhurst RM, Wellems TE. Plasmodium species (malaria). In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, PA: Churchill Livingstone Elsevier; 2010.

33.  Assistant Secretary of Defense for Health Affairs. Guidance on Medications for Prophylaxis of Malaria. HA-Policy 13-002. 15 April 2013.

34.  Defense Health Agency. Procedural Instruction 6490.03. Deployment Health Procedures. 17 December 2019.

 

FIGURE 1. Numbers of malaria cases, by Plasmodium species and calendar year of diagnosis or report, active and reserve components, U.S. Armed Forces, 2020

FIGURE 2. Annual numbers of cases of malaria cases, by location of acquisition, U.S. Armed Forces, 2011–2020

FIGURE 3. Cumulative numbers of diagnoses and reported cases of malaria, by month of clinical presentation or diagnosis, U.S. Armed Forces, January 2011–December 2020

TABLE 1. ICD-9 and ICD-10 diagnosis codes used in defining cases of malaria from the records for inpatient encounters (hospitalizations)

TABLE 2. Malaria cases by Plasmodium species and selected demographic characteristics, active and reserve components, U.S. Armed Forces, 2020

TABLE 1. ICD-9 and ICD-10 diagnosis codes used in defining cases of malaria from the records for inpatient encounters (hospitalizations)

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Infographic
2/5/2018
On 29 July 2016, the U.S. Coast Guard Training Center Cape May (TCCM), NJ, identified an increase in febrile respiratory illness (FRI) among recruits who were unvaccinated against seasonal influenza as a result of the annual vaccine’s expiration. This report characterizes the outbreak and containment measures implemented at TCCM during the outbreak period. In 2016, respiratory infections affected more than 250,000 U.S. service members and comprised approximately 22% of medical encounters among military recruit populations – who are highly susceptible to respiratory infections. Seasonal influenza and rhinovirus are two of the leading respiratory pathogens. During the Surveillance Period: 115 recruits reported respiratory infection symptoms. Pie chart 1 shows the following data: •	41 (35.7%) suspected cases •	74 (64.3%) confirmed cases Among confirmed cases, lab specimens tested positive for: •	Influenza A 34 (45.9%) •	Rhinovirus 28 (37.8%) •	Influenza A and rhinovirus co-infection 11 (14.9%) •	Rhinovirus and adenovirus co-infection 1 (1.4%) Data above depicted in pie chart 2. •	24 July – 6 August, Influenza predominated •	7 August – 20 August, Rhinovirus predominated Although the outbreak significantly affected operations at TCCM, a timely and comprehensive response resulted in containment of the outbreak within 5 weeks. Key Factor for Outbreak Control •	Rapid detection through FRI sentinel surveillance •	Quick decision-making •	Streamlined response by using a single chain of command •	Rapid implementation of both nonpharmaceutical and pharmaceutical interventions Access the full report in the January 2018 MSMR (Vol. 25, No. 1). Go to: www.Health.mil/MSMR

This report characterizes the outbreak and containment measures implemented at the U.S. Coast Guard Training Center Cape May (TCCM), New Jersey, during a July 24 – August 21, 2016 outbreak period.

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Health Readiness | Medical Surveillance Monthly Report | Integrated Biosurveillance | Influenza Summary and Reports

Department of Defense Global, Laboratory-based Influenza Surveillance Program’s Influenza vaccine effectiveness estimates and surveillance trends, 2016 – 2017 Influenza Season

Infographic
2/5/2018
Each year, the Department of Defense (DoD) Global, Laboratory-based Influenza Surveillance Program performs surveillance for influenza among service members of the DoD and their dependent family members. In addition to routine surveillance, vaccine effectiveness (VE) studies are performed and results are shared with the Food and Drug Administration, Centers for Disease Control and Prevention, and the World Health Organization for vaccine evaluation. This report documents the annual surveillance trends for the 2016 – 2017 influenza season and the end-of-season VE results. The analysis was performed by the U.S. Air Force School of Aerospace Medicine Epidemiology Laboratory, and the DoD Influenza Surveillance Program staff at Wright-Patterson Air Force Base, OH. FINDINGS: A total of 5,555 specimens were tested from 84 locations: •	2,486 (44.7%) negative •	1,382 (24.9%) influenza A •	1,093 (19.7%) other respiratory pathogens •	443 (8.0%) influenza B •	151 (2.7%) co-infections The predominant influenza strain was A (H3N2), representing 73.8% of all circulating influenza. Pie chart displays this information. Graph showing the numbers and percentages of respiratory specimens positive for influenza viruses, and numbers of influenza viruses identified, by type, by surveillance week, Department of Defense healthcare beneficiaries, 2016 – 2017 influenza season displays. The vaccine effectiveness (VE) for this season was slightly lower than for the 2015 – 2016 season, which had a 63% (95% confidence interval: 53% - 71%) adjusted VE. The adjusted VE for the 2016 – 2017 season was 48% protective against all types of influenza.  Access the full report in the January 2018 MSMR (Vol. 25, No. 1). Go to: www.Health.mil/MSMR

This infographic documents the annual surveillance trends for the 2016 – 2017 influenza season and the end-of-season vaccine effectiveness.

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Health Readiness | Influenza Summary and Reports | Medical Surveillance Monthly Report | Vaccine-Preventable Diseases | Force Health Protection

2018 #ColdReadiness Twitter chat recap: Preventing cold weather injuries for service members and their families

Fact Sheet
2/5/2018

To help protect U.S. armed forces, the Armed Forces Health Surveillance Branch (AFHSB) hosted a live #ColdReadiness Twitter chat on Wednesday, January 24th, 12-1:30 pm EST to discuss what service members and their families need to know about winter safety and preventing cold weather injuries as the temperatures drop. This fact sheet documents highlights from the Twitter chat.

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Insomnia and motor vehicle accident-related injuries, Active Component, U.S. Armed Forces, 2007 – 2016

Infographic
1/25/2018
Insomnia is the most common sleep disorder in adults and its incidence in the U.S. Armed Forces is increasing. A potential consequence of inadequate sleep is increased risk of motor vehicle accidents (MVAs). MVAs are the leading cause of peacetime deaths and a major cause of non-fatal injuries in the U.S. military members. To examine the relationship between insomnia and motor vehicle accident-related injuries (MVAs) in the U.S. military, this retrospective cohort study compared 2007 – 2016 incidence rates of MVA-related injuries between service members with diagnosed insomnia and service members without a diagnosis of insomnia. After adjustment for multiple covariates, during 2007 – 2016, active component service members with insomnia had more than double the rate of MVA-related injuries, compared to service members without insomnia. Findings:  •	Line graph shows the annual rates of motor vehicle accident-related injuries, active component service members with and without diagnoses of insomnia, U.S. Armed Forces, 2007 – 2016  •	Annual rates of MVA-related injuries were highest in the insomnia cohort in 2007 and 2008, and lowest in 2016 •	There were 5,587 cases of MVA-related injuries in the two cohorts during the surveillance period. •	Pie chart displays the following data: 1,738 (31.1%) in the unexposed cohort and 3,849 (68.9%) in the insomnia cohort The highest overall crude rates of MVA-related injuries were seen in service members who were: •	Less than 25 years old •	Junior enlisted rank/grade •	Armor/transport occupation •	 •	With a history of mental health diagnosis •	With a history of alcohol-related disorders Access the full report in the December 2017 (Vol. 24, No. 12). Go to www.Health.mil/MSMR Image displays a motor vehicle accident.

To examine the relationship between insomnia and motor vehicle accident-related injuries (MVAs) in the U.S. military, this retrospective cohort study compared 2007 – 2016 incidence rates of MVA-related injuries between service members with diagnosed insomnia and service members without a diagnosis of insomnia.

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Seizures among Active Component service members, U.S. Armed Forces, 2007 – 2016

Infographic
1/25/2018
This retrospective study estimated the rates of seizures diagnosed among deployed and non-deployed service members to identify factors associated with seizures and determine if seizure rates differed in deployment settings. It also attempted to evaluate the associations between seizures, traumatic brain injury (TBI), and post-traumatic stress disorder (PTSD) by assessing correlations between the incidence rates of seizures and prior diagnoses of TBI and PTSD. Seizures have been defined as paroxysmal neurologic episodes caused by abnormal neuronal activity in the brain. Approximately one in 10 individuals will experience a seizure in their lifetime. Line graph 1: Annual crude incidence rates of seizures among non-deployed service members, active component, U.S. Armed Forces data •	A total of 16,257 seizure events of all types were identified among non-deployed service members during the 10-year surveillance period. •	The overall incidence rate was 12.9 seizures per 10,000 person-years (p-yrs.) •	There was a decrease in the rate of seizures diagnosed in the active component of the military during the 10-year period. Rates reached their lowest point in 2015 – 9.0 seizures per 10,000 p-yrs. •	Annual rates were markedly higher among service members with recent PTSD and TBI diagnoses, and among those with prior seizure diagnoses. Line graph 2: Annual crude incidence rates of seizures by traumatic brain injury (TBI) and recent post-traumatic stress disorder (PTSD) diagnosis among non-deployed active component service members, U.S. Armed Forces •	For service members who had received both TBI and PTSD diagnoses, seizure rates among the deployed and the non-deployed were two and three times the rates among those with only one of those diagnoses, respectively. •	Rates of seizures tended to be higher among service members who were: in the Army or Marine Corps, Female, African American, Younger than age 30, Veterans of no more than one previous deployment, and in the occupations of combat arms, armor, or healthcare Line graph 3: Annual crude incidence rates of seizures diagnosed among service members deployed to Operation Enduring Freedom, Operation Iraqi Freedom, or Operation New Dawn, U.S. Armed Forces, 2008 – 2016  •	A total of 814 cases of seizures were identified during deployment to operations in Iraq and Afghanistan during the 9-year surveillance period (2008 – 2016). •	For deployed service members, the overall incidence rate was 9.1 seizures per 10,000 p-yrs. •	Having either a TBI or recent PTSD diagnosis alone was associated with a 3-to 4-fold increase in the rate of seizures. •	Only 19 cases of seizures were diagnosed among deployed individuals with a recent PTSD diagnosis during the 9-year surveillance period. •	Overall incidence rates among deployed service members were highest for those in the Army, females, those younger than age 25, junior enlisted, and in healthcare occupations. Access the full report in the December 2017 MSMR (Vol. 24, No. 12). Go to www.Health.mil/MSMR

This infographic documents a retrospective study which estimated the rates of seizures diagnosed among deployed and non-deployed service members to identify factors associated with seizures and determine if seizure rates differed in deployment settings. The study also evaluated the associations between seizures, traumatic brain injury (TBI), and post-traumatic stress disorder (PTSD) by assessing correlations between the incidence rates of seizures and prior diagnoses of TBI and PTSD.

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Health Readiness | Posttraumatic Stress Disorder | Armed Forces Health Surveillance Branch | Medical Surveillance Monthly Report

Exertional heat injuries pose annual threat to U.S. service members

Article
7/20/2017
Two U.S. service members perform duties in warm weather where they may be exposed to extreme heat conditions and a higher risk of heat illness.

Exertional heat injuries pose annual threat to U.S. service members, according to a study published in Defense Health Agency’s Armed Forces Health Surveillance Branch (AFHSB) peer-reviewed journal, the Medical Surveillance Monthly Report.

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Demographic and Military Traits of Service Members Diagnosed as Traumatic Brain Injury Cases

Fact Sheet
3/30/2017

This fact sheet provides details on the demographic and military traits of service members diagnosed as traumatic brain injury (TBI) cases during a 16-year surveillance period from 2001 through 2016, a total of 276,858 active component service members received first-time diagnoses of TBI - a structural alteration of the brain or physiological disruption of brain function caused by an external force.

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Armed Forces Health Surveillance Branch | Medical Surveillance Monthly Report

Heat Illnesses by Location, Active Component, U.S. Armed Forces, 2012-2016 Fact Sheet

Fact Sheet
3/30/2017

This fact sheet provides details on heat illnesses by location during a five-year surveillance period from 2012 through 2016. 11,967 heat-related illnesses were diagnosed at more than 250 military installations and geographic locations worldwide. Three Army Installations accounted for close to one-third of all heat illnesses during the period.

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Armed Forces Health Surveillance Branch | Medical Surveillance Monthly Report
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