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The association of percentage energy from fat and colon cancer risk among members of the US military.

Publication Status: Published

Sponsoring Organization: Defense Health Agency (formerly TRICARE Management Activity)

Sponsoring Office: Uniformed Services University of Health Sciences

Congressionally Mandated: No

Funding Source: Undetermined

Release Date/Publication: July 01, 2014

Principle Investigator Status: Government

Primary DoD Data Source: Defense Medical Surveillance System

Secondary DoD Data Source:

Abstract

Epidemiologic studies have previously reported an association between high fat intake and colon cancer risk. However, findings have generally been inconclusive. This study aimed to investigate the association between fat as a percentage of energy intake and colon cancer risk. Study subjects included 215 cases and 215 matched controls identified by the Defense Medical Surveillance System. Percentage energy from fat (Pfat) was estimated using a short dietary screener developed by the National Cancer Institute for two time periods: the year before the first blood draw and the year before colon cancer diagnosis. Conditional logistic regression analysis was used to assess the relationship between colon cancer risk and Pfat. Odds ratios and 95% confidence intervals (CIs) were calculated. Compared with the lowest quartile of Pfat, the adjusted odds of having colon cancer were 2.00 (95% CI 0.96-4.18), 2.83 (95% CI 1.41-5.66), and 3.37 (95% CI 1.58-7.17), respectively, for the second, third, and highest quartiles in the year before cancer diagnosis. Similar results were observed for Pfat at an earlier time point. Our findings suggest a positive association between Pfat and colon cancer in the US military population.

Citation:

Shao S, Kao TC, Eckhaus J, Bourgeois J, Perera K, Zhu K. The association of percentage energy from fat and colon cancer risk among members of the US military. Eur J Cancer Prev. 2014 Jul 29.

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