Back to Top Skip to main content

Update: Exertional Hyponatremia, Active Component, U.S. Armed Forces, 2003–2018

Drink water the day before and during physical activity or if heat is going to become a factor. (Photo Courtesy: U.S. Air Force) Drink water the day before and during physical activity or if heat is going to become a factor. (U.S. Air Force photo)

Recommended Content:

Medical Surveillance Monthly Report

ABSTRACT

From 2003 through 2018, there were 1,579 incident diagnoses of exertional hyponatremia among active component service members, for a crude overall incidence rate of 7.2 cases per 100,000 person-years (p-yrs). Compared to their respective counterparts, females, those less than 20 years old, and recruit trainees had higher overall incidence rates of exertional hyponatremia diagnoses. The overall incidence rate during the 16-year period was highest in the Marine Corps, intermediate in the Army and Air Force, and lowest in the Navy. Overall rates during the surveillance period were highest among Asian/Pacific Islander and non-Hispanic white service members and lowest among non-Hispanic black service members. Between 2003 and 2018, crude annual incidence rates of exertional hyponatremia peaked in 2010 (12.7 per 100,000 p-yrs) and then decreased to 5.3 cases per 100,000 p-yrs in 2013 before increasing in 2014 and 2015. The crude annual rate in 2018 (6.3 per 100,000 p-yrs) represented a decrease of 26.5% from 2015. Service members and their supervisors must be knowledgeable of the dangers of excessive water consumption and the prescribed limits for water intake during prolonged physical activity (e.g., field training exercises, personal fitness training, and recreational activities) in hot, humid weather.

WHAT ARE THE NEW FINDINGS?    

During 2003–2018, annual numbers and rates of diagnoses of exertional hyponatremia among active component U.S. military members were relatively stable from year to year with the exception of 2009–2011 when rates were dramatically higher. Overall incidence rates of exertional hyponatremia by subgroups of demographic and military characteristics were generally similar to those reported in previous MSMR updates.

WHAT IS THE IMPACT ON READINESS AND FORCE HEALTH PROTECTION?

Exertional hyponatremia continues to pose a health risk to U.S. military members and can significantly impair performance and reduce combat effectiveness. Military members (particularly recruit trainees and women) and their supervisors must be vigilant for early signs of heat-related illnesses, intervene immediately and appropriately (but not excessively) in such cases, and heed the recently validated guidance on fluid intake.

BACKGROUND

Exertional (or exercise-associated) hyponatremia refers to a low serum, plasma, or blood sodium concentration (below 135 milliequivalents/liter) that develops during or up to 24 hours following prolonged physical activity.1 Acute hyponatremia creates an osmotic imbalance between fluids outside and inside of cells. This osmotic gradient causes water to flow from outside to inside the cells of various organs, including the lungs (which can cause pulmonary edema) and brain (which can cause cerebral edema), producing serious and sometimes fatal clinical effects.1,2 Swelling of the brain increases intracranial pressure, which can decrease cerebral blood flow and disrupt brain function, potentially causing hypotonic encephalopathy, seizures, or coma. Rapid and definitive treatment is needed to relieve increasing intracranial pressure and prevent brain stem herniation, which can result in respiratory arrest.2–4

Serum sodium concentration is determined mainly by the total content of exchangeable body sodium and potassium relative to total body water. Thus, exertional hyponatremia can result from loss of sodium and/or potassium, a relative excess of body water, or a combination of both.5,6 However, overconsumption of fluids and the resultant excess of total body water are the primary driving factors in the development of exertional hyponatremia.1,7,8 Other important factors include the persistent secretion of antidiuretic hormone (arginine vasopressin), excessive sodium losses in sweat, and inadequate sodium intake during prolonged physical exertion, particularly during heat stress.2–4,9 The importance of sodium losses through sweat in the development of exertional hyponatremia is influenced by the fitness level of the individual. Less fit individuals generally have a higher sweat sodium concentration, a higher rate of sweat production, and an earlier onset of sweating during exercise.10–12

This report uses a surveillance case definition for exertional hyponatremia to estimate the frequencies, rates, trends, geographic locations, and demographic and military characteristics of exertional hyponatremia cases among U.S. military members from 2003 through 2018.13

METHODS

The surveillance period was 1 January 2003 through 31 December 2018. The surveillance population included all individuals who served in an active component of the U.S. Army, Navy, Air Force, or Marine Corps at any time during the surveillance period. All data used to determine incident exertional hyponatremia diagnoses were derived from records routinely maintained in the Defense Medical Surveillance System (DMSS). These records document both ambulatory encounters and hospitalizations of active component service members of the U.S. Armed Forces in fixed military and civilian (if reimbursed through the Military Health System [MHS]) treatment facilities worldwide. In-theater diagnoses of hyponatremia were identified from medical records of service members deployed to Southwest Asia/Middle East and whose healthcare encounters were documented in the Theater Medical Data Store (TMDS). TMDS records became available in the DMSS beginning in 2008.

For this analysis, a case of exertional hyponatremia was defined as 1) a hospitalization or ambulatory visit with a primary (first-listed) diagnosis of “hypo-osmolality and/or hyponatremia” (International Classification of Diseases, 9th Revision [ICD-9]: 276.1; International Classification of Diseases, 10th Revision [ICD-10]: E87.1) and no other illness or injury-specific diagnoses (ICD-9: 001–999) in any diagnostic position or 2) both a diagnosis of “hypo-osmolality and/or hyponatremia” (ICD-9: 276.1; ICD-10: E87.1) and at least 1 of the following within the first 3 diagnostic positions: “fluid overload” (ICD-9: 276.9; ICD-10: E87.70, E87.79), “alteration of consciousness” (ICD-9: 780.0*; ICD-10: R40.*), “convulsions” (ICD-9: 780.39; ICD-10: R56.9), “altered mental status” (ICD-9: 780.97; ICD-10: R41.82), “effects of heat/light” (ICD-9: 992.0–992.9; ICD-10: T67.0*–T67.9*), or “rhabdomyolysis” (ICD-9: 728.88; ICD-10: M62.82).13

Medical encounters were not considered case-defining events if the associated records included the following diagnoses in any diagnostic position: alcohol/illicit drug abuse; psychosis, depression, or other major mental disorders; endocrine (e.g., pituitary or adrenal) disorders; kidney diseases; intestinal infectious diseases; cancers; major traumatic injuries; or complications of medical care. Each individual could be considered an incident case of exertional hyponatremia only once per calendar year.

For surveillance purposes, a “recruit trainee” was defined as an active component member in an enlisted grade (E1–E4) who was assigned to 1 of the services’ recruit training locations (per the individual’s initial military personnel record). For this report, each service member was considered a recruit trainee for the period corresponding to the usual length of recruit training in his/her service. Recruit trainees were considered a separate category of enlisted service members in summaries of exertional hyponatremia by military grade overall.

In-theater diagnoses of exertional hyponatremia were analyzed separately using the same case-defining criteria and incidence rules that were applied to identify incident cases at fixed treatment facilities. Records of medical evacuations from the U.S. Central Command (CENTCOM) area of responsibility (AOR) (e.g., Iraq and Afghanistan) to a medical treatment facility outside the CENTCOM AOR were analyzed separately. Evacuations were considered case defining if the affected service members met the above criteria in a permanent military medical facility in the U.S. or Europe from 5 days before to 10 days after their evacuation dates.

The new electronic health record for the MHS, MHS GENESIS, was implemented at several military treatment facilities during 2017. Medical data from sites that are using MHS GENESIS are not available in the DMSS. These sites include Naval Hospital Oak Harbor, Naval Hospital Bremerton, Air Force Medical Services Fairchild, and Madigan Army Medical Center. Therefore, medical encounter data for individuals seeking care at any of these facilities during 2017–2018 were not included in this analysis.

RESULTS

During 2003–2018, permanent medical facilities recorded 1,579 incident diagnoses of exertional hyponatremia among active component service members, for a crude overall incidence rate of 7.2 cases per 100,000 person-years (p-yrs) (Table 1). In 2018, there were 82 incident diagnoses of exertional hyponatremia (incidence rate: 6.3 per 100,000 p-yrs) among active component service members. During this year, males represented 85.4% of exertional hyponatremia cases (n=70); the annual incidence rate was slightly higher among males (6.5 per 100,000 p-yrs) than females (5.6 per 100,000 p-yrs) (Table 1). The highest age group-specific annual incidence rates in 2018 were among the youngest (less than 20 years old) service members. Although the Army had the most cases during 2018 (n=29), the highest incidence rate was among members of the Marine Corps (10.8 per 100,000 p-yrs). In 2018, there were only 11 cases of exertional hyponatremia among recruit trainees, but their incidence rate was 6 times that of officers and more than 7 times that of other enlisted members (Table 1). 

During the 16-year surveillance period, females had a slightly higher overall incidence rate of exertional hyponatremia diagnoses than males (Table 1). The overall incidence rate was highest in the Marine Corps (15.2 per 100,000 p-yrs) and lowest in the Navy (4.8 per 100,000 p-yrs). Overall rates during the surveillance period were highest among Asian/Pacific Islander (8.3 per 100,000 p-yrs) and non-Hispanic white service members (8.1 per 100,000 p-yrs) and lowest among non-Hispanic black service members (5.4 per 100,000 p-yrs). Although recruit trainees accounted for less than one-tenth (9.1%) of all exertional hyponatremia cases, their overall crude incidence rate was 5.1 and 3.6 times the rates among other enlisted members and officers, respectively (Table 1). During the 16-year period, 86.3% (n=1,362) of all cases were diagnosed and treated without having to be hospitalized (data not shown).

Between 2003 and 2018, crude annual rates of incident exertional hyponatremia diagnoses peaked in 2010 (12.7 per 100,000 p-yrs) and then decreased to 5.3 cases per 100,000 p-yrs in 2013 before increasing in 2014 and 2015. The crude annual incidence rate in 2018 (6.3 per 100,000 p-yrs) represented a decrease of 26.5% from 2015 (Figure 1). During 2003–2018, annual incidence rates of exertional hyponatremia diagnoses were consistently higher among those in the Marine Corps compared to those in the other services, with the overall trend in rates primarily influenced by the trend among Marine Corps members (Figure 2). Between 2017 and 2018, annual incidence rates decreased among Marine Corps members, increased among members of the Navy, and remained relatively stable among members of the Army and the Air Force (Figure 2).

Exertional hyponatremia by location

During the 16-year surveillance period, exertional hyponatremia cases were diagnosed at the medical treatment facilities of more than 150 U.S. military installations and geographic locations worldwide; however, 14 U.S. installations contributed 20 or more cases each and accounted for 47.6% of the total cases (Table 2). The installation with the most exertional hyponatremia cases overall was the Marine Corps Recruit Depot (MCRD) Parris Island/Beaufort, SC (n=205).

Exertional hyponatremia in Iraq and Afghanistan

From 2008 through 2018, a total of 18 cases of exertional hyponatremia were diagnosed and treated in Iraq and Afghanistan. Deployed service members who were affected by exertional hyponatremia were most frequently male (n=16; 88.9%), non-Hispanic white (n=14; 77.8%), aged 20–24 years (n=8; 44.4%), in the Army (n=13; 72.2%), enlisted (n=15; 83.3%), and in combat-specific (n=7; 38.9%) or communications/intelligence (n=4; 22.2%) occupations (data not shown). During the entire surveillance period, 9 service members were medically evacuated from Iraq or Afghanistan for exertional hyponatremia (data not shown).

EDITORIAL COMMENT

This report documents that after a 2-year period (2014–2015) of elevated numbers and rates of exertional hyponatremia among active component U.S. military members, numbers and rates of diagnoses decreased slightly during 2016–2018. Subgroup-specific patterns of overall incidence rates of exertional hyponatremia (e.g., sex, age, race/ethnicity, service, and military status) were generally similar to those reported in previous MSMR updates.14,15 It is important to note that in MSMR analyses prior to April 2018, in-theater cases were included if there was a diagnosis of hypo-osmolality and/or hyponatremia in any diagnostic position. Beginning last year, the same case-defining criteria that were applied to inpatient and outpatient encounters were applied to the in-theater encounters. Therefore, the results of the in-theater analysis are not comparable to those presented in earlier MSMR updates.

Several important limitations should be considered when interpreting the results of this analysis. First, there is no diagnostic code specific for exertional hyponatremia. Thus, for surveillance purposes, cases of presumed exertional hyponatremia were ascertained from records of medical encounters that included diagnoses of hypo-osmolality and/or hyponatremia but not of other conditions (e.g., metabolic, renal, psychiatric, or iatrogenic disorders) that increase the risk of hyponatremia in the absence of physical exertion or heat stress. As such, exertional hyponatremia cases here likely include hyponatremia from both exercise- and non–exercise-related conditions. Consequently, the results of this analysis should be considered estimates of the actual incidence of symptomatic exertional hyponatremia from excessive water consumption among U.S. military members. In addition, the accuracy of estimated numbers, rates, trends, and correlates of risk depends on the completeness and accuracy of diagnoses that are documented in standardized records of relevant medical encounters. As a result, an increase in recorded diagnoses indicative of exertional hyponatremia may reflect, at least in part, increasing awareness of, concern regarding, and aggressive management of incipient cases by military supervisors and primary healthcare providers.

In the past, concerns about hyponatremia resulting from excessive water consumption were focused at training—particularly recruit training—installations. In this analysis, rates were relatively high among the youngest, and hence the most junior service members, and the highest numbers of cases tended to be diagnosed at medical facilities that support large recruit training centers (e.g., MCRD Parris Island/Beaufort, SC; Fort Benning, GA; and Joint Base San Antonio–Lackland Air Force Base, TX) and large Army and Marine Corps combat units (e.g., Fort Bragg, NC, and Marine Corps Base Camp Lejeune/Cherry Point, NC).

In response to previous historical cases of exertional hyponatremia in the U.S. military, the guidelines for fluid replacement during military training in hot weather were revised and promulgated in 1998.16–19 The revised guidelines were designed to protect service members from not only heat injury but also hyponatremia due to excessive water consumption by limiting fluid intake regardless of heat category or work level to no more than 1.5 quarts hourly and 12 quarts daily.17,18 There were fewer hospitalizations of soldiers for hyponatremia due to excessive water consumption during the year after (vs. the year before) implementation of the new guidelines.20 In 2003, the revised guidelines were included in the multi-service Technical Medical Bulletin 507, Heat Stress Control and Heat Casualty Management that provides guidance to military and civilian healthcare providers, allied medical personnel, and military leadership.21 A recent study found that this military fluid intake guidance remains valid for preventing excessive dehydration as well as overhydration and can be used by military health professionals and leadership to adequately maintain a normal level of hydration in service members working in the 5 designated flag conditions (levels of heat/humidity stress) while wearing contemporary uniform configurations (including protective gear/equipment) across a range of metabolic rates.22

During endurance events, a “drink-to-thirst” or a programmed fluid intake plan of 400–800 mL per estimated hour of activity has been suggested to limit the risk of exertional hyponatremia, although this rate should be customized to the individual’s tolerance and experience.4,8,18,20 In addition to these guidelines, reducing the availability of fluids may help prevent exertional hyponatremia during endurance events.23,24 Carrying a maximum fluid load of 1 quart of fluid per estimated hour of activity and encouraging a “drink-to-thirst” approach to hydration may help prevent both severe exertional hyponatremia and dehydration during military training exercises and recreational hikes that exceed 2–3 hours.4,8,23,24

Women had relatively high rates of hyponatremia during the entire surveillance period; women may be at greater risk because of lower fluid requirements and longer periods of exposure to risk during some training exercises (e.g., land navigation courses or load-bearing marches).9 The finding that the overall incidence of women experiencing exertional hyponatremia was greater than that of men in this analysis is similar to results found among samples of marathon runners in the general population. However, a large study of marathon runners suggested that the apparent sex difference did not remain after adjustment for body mass index and racing times.25–27

In many circumstances (e.g., recruit training and Ranger School), military trainees rigorously adhere to standardized training schedules regardless of weather conditions. In hot and humid weather, commanders, supervisors, instructors, and medical support staff must be aware of and enforce guidelines for work–rest cycles and water consumption. The finding in this report that most cases of hyponatremia were treated in outpatient settings suggests that monitoring by supervisors and medical staff identified most cases during the early and less severe manifestations of hyponatremia.

In general, service members and their supervisors must be knowledgeable of the dangers of excessive water consumption as well as the prescribed limits for water intake during prolonged physical activity (e.g., field training exercises, personal fitness training, and recreational activities) in hot, humid weather. Military members (particularly recruit trainees and women) and their supervisors must be vigilant for early signs of heat-related illnesses and intervene immediately and appropriately (but not excessively) in such cases. Finally, the recent validation of the current fluid intake guidance highlights its importance as a resource to leadership in sustaining military readiness.22

REFERENCES

1. Hew-Butler T, Rosner MH, Fowkes-Godek S, et al. Statement of the Third International Exercise-Associated Hyponatremia Consensus Development Conference, Carlsbad, California, 2015. Clin J Sport Med. 2015;25(4):303–320.

2. Montain SJ. Strategies to prevent hyponatremia during prolonged exercise. Curr Sports Med Rep. 2008;7(4):S28–S35.

3. Chorley J, Cianca J, Divine J. Risk factors for exercise-associated hyponatremia in non-elite marathon runners. Clin J Sport Med. 2007;17(6):471–477.

4. Hew-Butler T, Loi V, Pani A, Rosner MH. Exercise-associated hyponatremia: 2017 update. Front Med (Lausanne). 2017;4:21

5. Edelman IS, Leibman J, O’Meara MP, Birkenfeld LW. Interrelations between serum sodium concentration, serum osmolarity and total exchangeable sodium, total exchangeable potassium and total body water. J Clin Invest. 1958;37(9):1236–1256.

6. Nguyen MK, Kurtz I. Determinants of plasma water sodium concentration as reflected in the Edelman equation: role of osmotic and Gibbs-Donnan equilibrium. Am J Physiol Renal Physiol. 2004;286(5):F828–F837.

7. Noakes TD, Sharwood K, Speedy D, et al. Three independent biological mechanisms cause exercise-associated hyponatremia: evidence from 2,135 weighed competitive athletic performances. Proc Natl Acad Sci U S A. 2005;102(51):18550–18555.

8. Oh RC, Malave B, Chaltry JD. Collapse in the heat—from overhydration to the emergency room—three cases of exercise-associated hyponatremia associated with exertional heat illness. Mil Med. 2018;183(3–4):e225–e228.

9. Carter R III. Exertional heat illness and hyponatremia: an epidemiological prospective. Curr Sports Med Rep. 2008;7(4):S20–S27.

10. Buono MJ, Ball KD, Kolkhorst FW. Sodium ion concentration vs. sweat rate relationship in humans. J Appl Physiol (1985). 2007;103(3):990–994.

11. Buono MJ, Sjoholm NT. Effect of physical training on peripheral sweat production. J Appl Physiol (1985). 1988;65(2):811–814.

12. Nadel ER, Pandolf KB, Roberts MF, Stolwijk JA. Mechanisms of thermal acclimation to exercise and heat. J Appl Physiol. 1974;37(4):515–520.

13. Armed Forces Health Surveillance Branch. Surveillance Case Definition. Hyponatremia. March 2017. https://health.mil/Military-Health-Topics/Combat-Support/Armed-Forces-Health-Surveillance-Branch/Epidemiology-and-Analysis/Surveillance-Case-Definitions. Accessed 6 March 2019.

14. Armed Forces Health Surveillance Branch. Update: Exertional hyponatremia, active component, U.S. Armed Forces, 2001–2016. MSMR. 2017;24(3)19–23.

15. Armed Forces Health Surveillance Branch. Update: Exertional hyponatremia, active component, U.S. Armed Forces, 2002–2017. MSMR. 2018;25(4)18–22.

16. Army Medical Surveillance Activity. Case reports: Hyponatremia associated with heat stress and excessive water consumption: Fort Benning, GA; Fort Leonard Wood, MO; Fort Jackson, SC, June–August 1997. MSMR. 1997;3(6):2–3,8.

17. Department of the Army, Office of the Surgeon General. Memorandum, subject: Policy guidance for fluid replacement during training, dated 29 April 1998.

18. Montain S., Latzka WA, Sawka MN. Fluid replacement recommendations for training in hot weather. Mil Med. 1999;164(7):502–508.

19. O’Brien KK, Montain SJ, Corr WP, Sawka MN, Knapik JJ, Craig SC. Hyponatremia associated with overhydration in U.S. Army trainees. Mil Med. 2001;166(5):405–410.

20. Army Medical Surveillance Activity. Surveillance trends: Hyponatremia associated with heat stress and excessive water consumption: the impact of education and a new Army fluid replacement policy. MSMR. 1999;5(2):2–3,8–9.

21. Headquarters, Departments of the Army and Air Force (DoTAaA). Heat stress control and heat casualty management. Technical Bulletin Medical 507. Air Force Pamphlet, 48–152(I). 2003.

22. Luippold AJ, Charkoudian N, Kenefick RW, et al. Update: Efficacy of military fluid intake guidelines. Mil Med. 2018;183(9/10):e338–e342.

23. Hew-Butler T, Verbalis JG, Noakes TD. Updated fluid recommendation: Position statement from the International Marathon Medical Directors Association (IMMDA). Clin J Sport Med. 2006;16(4):283–292.

24. Thomas DT, Erdman KA, Burke LM. American College of Sports Medicine Joint Position Statement. Nutrition and athletic performance. Med Sci Sport Exerc. 2016;48(3):543–568.

25. Almond CS, Shin AY, Fortescue EB, et al. Hyponatremia among runners in the Boston Marathon. N Engl J Med. 2005;352(15):1550–1556.

26. Ayus JC, Varon J, Arieff AI. Hyponatremia, cerebral edema, and noncardiogenic pulmonary edema in marathon runners. Ann Intern Med. 2000;132(9):711–714.

27. Hew TD, Chorley JN, Cianca JC, Divine JG. The incidence, risk factors, and clinical manifestations of hyponatremia in marathon runners. Clin J Sport Med. 2003;13(1):41–47.

 

Annual incident cases and rates of incident diagnoses of exertional hyponatremia, active component, U.S. Armed Forces, 2003–2018

Annual incidence rates of exertional hyponatremia, by service, active component, U.S. Armed Forces, 2003–2018

Incident casesa and ratesb of hyponatremia/overhydration diagnoses, active component, U.S. Armed Forces, January 2003–December 2018

Incident cases of exertional hyponatremia, by installation (with at least 20 cases during the period), active component, U.S. Armed Forces, 2003–2018

You also may be interested in...

Adenovirus

Infographic
3/1/2019
Adenovirus

During August–September 2016, U.S. Naval Academy clinical staff noted an increase in students presenting with acute respiratory illness (ARI). An investigation was conducted to determine the extent and cause of the outbreak.

Recommended Content:

Health Readiness | Armed Forces Health Surveillance Branch | Epidemiology and Analysis | Medical Surveillance Monthly Report | Public Health

Glaucoma

Infographic
3/1/2019
Glaucoma

This report describes an analysis using the Defense Medical Surveillance System to identify all active component service members with an incident diagnosis of glaucoma during the period between 2013 and 2017.

Recommended Content:

Health Readiness | Armed Forces Health Surveillance Branch | Epidemiology and Analysis | Medical Surveillance Monthly Report | Public Health

Malaria

Infographic
3/1/2019
Malaria

Since 1999, the Medical Surveillance Monthly Report has published regular updates on the incidence of malaria among U.S. service members. The MSMR’s focus on malaria reflects both historical lessons learned about this mosquito-borne disease and the continuing threat that it poses to military operations and service members’ health.

Recommended Content:

Health Readiness | Armed Forces Health Surveillance Branch | Epidemiology and Analysis | Medical Surveillance Monthly Report | Public Health

Update: Malaria, U.S. Armed Forces, 2018

Article
2/1/2019
Anopheles merus

Malaria infection remains an important health threat to U.S. service mem­bers who are located in endemic areas because of long-term duty assign­ments, participation in shorter-term contingency operations, or personal travel. In 2018, a total of 58 service members were diagnosed with or reported to have malaria. This represents a 65.7% increase from the 35 cases identi­fied in 2017. The relatively low numbers of cases during 2012–2018 mainly reflect decreases in cases acquired in Afghanistan, a reduction due largely to the progressive withdrawal of U.S. forces from that country. The percentage of cases of malaria caused by unspecified agents (63.8%; n=37) in 2018 was the highest during any given year of the surveillance period. The percent­age of cases identified as having been caused by Plasmodium vivax (10.3%; n=6) in 2018 was the lowest observed during the 10-year surveillance period. The percentage of malaria cases attributed to P. falciparum (25.9 %) in 2018 was similar to that observed in 2017 (25.7%), although the number of cases increased. Malaria was diagnosed at or reported from 31 different medical facilities in the U.S., Afghanistan, Italy, Germany, Djibouti, and Korea. Pro­viders of medical care to military members should be knowledgeable of and vigilant for clinical manifestations of malaria outside of endemic areas.

Recommended Content:

Medical Surveillance Monthly Report

Update: Incidence of Glaucoma Diagnoses, Active Component, U.S. Armed Forces, 2013–2017

Article
2/1/2019
Glaucoma

Glaucoma is an eye disease that involves progressive optic nerve damage and vision loss, leading to blindness if undetected or untreated. This report describes an analysis using the Defense Medical Surveillance System to identify all active component service members with an incident diagnosis of glaucoma during the period between 2013 and 2017. The analysis identified 37,718 incident cases of glaucoma and an overall incidence rate of 5.9 cases per 1,000 person-years (p-yrs). The majority of cases (97.6%) were diagnosed at an early stage as borderline glaucoma; of these borderline cases, 2.2% progressed to open-angle glaucoma during the study period. No incident cases of absolute glaucoma, or total blindness, were identified. Rates of glaucoma were higher among non-Hispanic black (11.0 per 1,000 p-yrs), Asian/Pacific Islander (9.5), and Hispanic (6.9) service members, compared with non-Hispanic white (4.0) service members. Rates among female service members (6.6 per 1,000 p-yrs) were higher than those among male service members (5.8). Between 2013 and 2017, incidence rates of glaucoma diagnoses increased by 75.4% among all service members.

Recommended Content:

Medical Surveillance Monthly Report

Outbreak of Acute Respiratory Illness Associated with Adenovirus Type 4 at the U.S. Naval Academy, 2016

Article
2/1/2019
Malaria case definition

Human adenoviruses (HAdVs) are known to cause respiratory illness outbreaks at basic military training (BMT) sites. HAdV type-4 and -7 vaccines are routinely administered at enlisted BMT sites, but not at military academies. During August–September 2016, U.S. Naval Academy clinical staff noted an increase in students presenting with acute respiratory illness (ARI). An investigation was conducted to determine the extent and cause of the outbreak. During 22 August–11 September 2016, 652 clinic visits for ARI were identified using electronic health records. HAdV-4 was confirmed by real-time polymerase chain reaction assay in 18 out of 33 patient specimens collected and 1 additional HAdV case was detected from hospital records. Two HAdV-4 positive patients were treated for pneumonia including 1 hospitalized patient. Molecular analysis of 4 HAdV-4 isolates identified genome type 4a1, which is considered vaccine-preventable. Understanding the impact of HAdV in congregate settings other than enlisted BMT sites is necessary to inform discussions regarding future HAdV vaccine strategy.

Recommended Content:

Medical Surveillance Monthly Report

Re-evaluation of the MSMR Case Definition for Incident Cases of Malaria

Article
2/1/2019
Anopheles merus

The MSMR has been publishing the results of surveillance studies of malaria since 1995. The standard MSMR case definition uses Medical Event Reports and records of hospitalizations in counting cases of malaria. This report summarizes the performance of the standard MSMR case definition in estimating incident cases of malaria from 2015 through 2017. Also explored was the potential surveillance value of including outpatient encounters with diagnoses of malaria or positive laboratory tests for malaria in the case definition. The study corroborated the relative accuracy of the MSMR case definition in estimating malaria incidence and provided the basis for updating the case definition in 2019 to include positive laboratory tests for malaria antigen within 30 days of an outpatient diagnosis.

Recommended Content:

Medical Surveillance Monthly Report

Acute Flaccid Myelitis Case Reporting

Infographic
1/29/2019
Acute Flaccid Myelitis Case Reporting

This case highlights important clinical characteristics of acute flaccid myelitis and emphasizes the importance of including AFM in the differential diagnosis when evaluating active duty service members and Military Health System beneficiaries presenting with paralysis.

Recommended Content:

Health Readiness | Armed Forces Health Surveillance Branch | Epidemiology and Analysis | Medical Surveillance Monthly Report | Public Health

Cardiovascular disease-related medical evacuations

Infographic
1/29/2019
Cardiovascular disease-related medical evacuations

This descriptive analysis summarizes the demographic characteristics, counts, rates and temporal trends for Cardiovascular disease-related medical evacuations from the CENTCOM area of responsibility. In addition, the percentage of those evacuated who had received pre-deployment diagnoses indicating cardiovascular risk is summarized. Responses to questions regarding health status and physician referrals on the DD2795 are also summarized.

Recommended Content:

Health Readiness | Armed Forces Health Surveillance Branch | Epidemiology and Analysis | Medical Surveillance Monthly Report | Public Health

Non-alcoholic fatty liver disease

Infographic
1/29/2019
HPV

At the time of this report, there were no published studies of non-alcoholic fatty liver disease (NAFLD) incidence over time among active component U.S. military personnel. Examining the incidence rates of NAFLD and their temporal trends among active component U.S. military members can provide insights into the future burden of NAFLD on the MHS.

Recommended Content:

Health Readiness | Armed Forces Health Surveillance Branch | Epidemiology and Analysis | Medical Surveillance Monthly Report | Public Health

Historical Perspective: Leptospirosis Outbreaks Affecting Military Forces

Article
1/1/2019
Acute Flaccid Myelitis

Leptospirosis is a widespread and highly prevalent bacterial zoonotic disease that is caused by pathogenic spirochetes of the genus Leptospira. It is transmitted to humans primarily through contact of abraded skin or mucous membranes with water or wet soil that has been contaminated with infected animal urine. Many wild and domestic animals are susceptible to infection by pathogenic Leptospira bacteria including rats, dogs, cattle, goats, sheep, and swine. Once chronically infected, a carrier animal can shed Leptospira bacteria in urine for long periods of time and Leptospira bacteria can survive in water or soil for weeks to months.higher among non-Hispanic white service members compared with those in other race/ethnicity groups. In both sexes, the annual rates of adrenal insufficiency and other disorders of adrenal gland increased slightly during the 16-year period.31.6 per 100,000 active component service members in 2017. Validation of ICD-9/ICD-10 diagnostic codes for MetS using the National Cholesterol Education Program Adult Treatment Panel III criteria is needed to establish the level of agreement between the two methods for identifying this condition.

Recommended Content:

Medical Surveillance Monthly Report

Acute Flaccid Myelitis: Case Report

Article
1/1/2019
Acute Flaccid Myelitis

In August 2018, the U.S. Centers for Disease Control and Prevention (CDC) noted an increased number of reports of patients in the U.S. having symptoms clinically compatible with acute flaccid myelitis (AFM). AFM is characterized by rapid onset of flaccid weakness in one or more limbs and distinct abnormalities of the spinal cord gray matter on magnetic resonance imaging (MRI). Clinical and laboratory data suggest that AFM is associated with an antecedent viral infection. AFM may be difficult to differentiate from other causes of paralysis and, given that it is rare, has the potential to be overlooked. This case highlights important clinical characteristics of AFM and emphasizes the importance of including AFM in the differential diagnosis when evaluating active duty service members and Military Health System (MHS) beneficiaries presenting with paralysis.31.6 per 100,000 active component service members in 2017. Validation of ICD-9/ICD-10 diagnostic codes for MetS using the National Cholesterol Education Program Adult Treatment Panel III criteria is needed to establish the level of agreement between the two methods for identifying this condition.

Recommended Content:

Medical Surveillance Monthly Report

Non-alcoholic Fatty Liver Disease (NAFLD), Active Component, U.S. Armed Forces, 2000–2017

Article
1/1/2019
Non-alcoholic fatty liver disease

During 2002–2017, the most common incident adrenal gland disorder among male and female service members was adrenal insufficiency and the least common was adrenomedullary hyperfunction. Adrenal insufficiency was diagnosed among 267 females (crude overall incidence rate: 8.2 cases per 100,000 person-years [p-yrs]) and 729 males (3.9 per 100,000 p-yrs). In both sexes, overall rates of other disorders of adrenal gland and Cushing’s syndrome were lower than for adrenal insufficiency but higher than for hyperaldosteronism, adrenogenital disorders, and adrenomedullary hyperfunction. Crude overall rates of adrenal gland disorders among females tended to be higher than those of males, with female:male rate ratios ranging from 2.1 for adrenal insufficiency to 5.5 for androgenital disorders and Cushing’s syndrome. The highest overall rates of adrenal insufficiency for males and females were among non-Hispanic white service members. Among females, rates of Cushing’s syndrome and other disorders of adrenal gland were 31.6 per 100,000 active component service members in 2017. Validation of ICD-9/ICD-10 diagnostic codes for MetS using the National Cholesterol Education Program Adult Treatment Panel III criteria is needed to establish the level of agreement between the two methods for identifying this condition.

Recommended Content:

Medical Surveillance Monthly Report

Cardiovascular Disease-related Medical Evacuations, Active and Reserve Components, U.S. Armed Forces, 1 October 2001–31 December 2017

Article
1/1/2019
Cardiovascular Diagnoses

From 1 October 2001 through 31 December 2017, a total of 697 medical evacuations of service members from the U.S. Central Command (CENTCOM) area of responsibility were followed by at least one medical encounter in a fixed medical facility outside the operational theater with a diagnosis of a cardiovascular disease (CVD). The vast majority of those (n=660; 94.7%) evacuated were males. More than a third of CVD-related evacuations (n=278, 39.9%) occurred in service members 45 years of age or older; slightly more than half (n=369; 52.9%) occurred in reserve or guard members. The most common CVD risk factors which had been diagnosed among evacuated service members prior to their deployment were hypertension (n=236; 33.9%) and hyperlipidemia (n=241; 34.9%). Much lower percentages had been previously diagnosed with obesity (n=74, 10.6%) or diabetes (n=21, 3.0%). More than 1 in 4 service members with a CVD-related medical evacuation had been diagnosed with more than one risk factor (n=182, 26.1%). Both limitations to the data available and strategies to reduce CVD morbidity in theater are discussed.31.6 per 100,000 active component service members in 2017. Validation of ICD-9/ICD-10 diagnostic codes for MetS using the National Cholesterol Education Program Adult Treatment Panel III criteria is needed to establish the level of agreement between the two methods for identifying this condition.

Recommended Content:

Medical Surveillance Monthly Report

Adrenal Gland Disorders, Active Component, U.S. Armed Forces, 2002–2017

Article
12/1/2018
Adrenal Glands

During 2002–2017, the most common incident adrenal gland disorder among male and female service members was adrenal insufficiency and the least common was adrenomedullary hyperfunction. Adrenal insufficiency was diagnosed among 267 females (crude overall incidence rate: 8.2 cases per 100,000 person-years [p-yrs]) and 729 males (3.9 per 100,000 p-yrs). In both sexes, overall rates of other disorders of adrenal gland and Cushing’s syndrome were lower than for adrenal insufficiency but higher than for hyperaldosteronism, adrenogenital disorders, and adrenomedullary hyperfunction. Crude overall rates of adrenal gland disorders among females tended to be higher than those of males, with female:male rate ratios ranging from 2.1 for adrenal insufficiency to 5.5 for androgenital disorders and Cushing’s syndrome. The highest overall rates of adrenal insufficiency for males and females were among non-Hispanic white service members. Among females, rates of Cushing’s syndrome and other disorders of adrenal gland were 31.6 per 100,000 active component service members in 2017. Validation of ICD-9/ICD-10 diagnostic codes for MetS using the National Cholesterol Education Program Adult Treatment Panel III criteria is needed to establish the level of agreement between the two methods for identifying this condition.

Recommended Content:

Medical Surveillance Monthly Report
<< < 1 2 3 4 5  ... > >> 
Showing results 61 - 75 Page 5 of 8

DHA Address: 7700 Arlington Boulevard | Suite 5101 | Falls Church, VA | 22042-5101

Some documents are presented in Portable Document Format (PDF). A PDF reader is required for viewing: Download a PDF Reader or learn more about PDFs.