In February 2022, President Biden reignited the 2016 White House Cancer Moonshot initiative, an effort across multiple federal agencies aimed to reduce the death rate from cancer by at least 50 percent over the next 25 years. The initiative is also focused on improving the experience of people and their families living with and surviving cancer, with a goal to ultimately end cancer.

A part of this effort, the DOD component is sponsored by the Uniformed Services University of the Health Sciences in Bethesda, Maryland.  In 2016, the DOD, Department of Veterans Affairs, and the National Cancer Institute created the Applied Proteogenomics Organizational Learning and Outcomes Network. The initial effort created a network of 13 DOD and VA hospitals that launched eight cancer-specific programs, including studies in lung, breast, prostate, ovarian, pancreatic, testicular, and brain cancers.

Over time, the Cancer Moonshot program will expand the APOLLO Network to all DHA hospitals and extend its research efforts to include all cancer types. The new APOLLO trial network is part of a recent White House "reignition" Fact Sheet: President Biden Reignites Cancer Moonshot to End Cancer as We Know It of the Cancer Moonshot.