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Military Health System

TBICoE Research

TBICoE supports a network of military treatment facilities and Department of Veterans Affairs medical centers with traumatic brain injury (TBI) research initiatives, including gap-driven analyses and Congressionally-directed programs such as the Section 721 Longitudinal Study of TBI and Section 734 investigation into the effects of blast exposure on Warfighter Brain Health and Performance.

TBICoE's extensive internal and external collaborations allow for clinical innovation and research along the continuum of care of TBI—from initial injury to acute and post-acute medical settings; rehabilitation; and ultimately a return to family, community, and work or continued duty.  

Beyond conducting research, TBICoE also periodically reviews available peer-reviewed scientific literature to summarize the state-of-the-science, consensus of medical approaches, as well as existing and new evidence of TBI research. Many of those documents are showcased below.

TBICoE Research Gaps and Priorities (2022-2024)

TBICoE Information Papers

The Impact of Mild Traumatic Brain Injury on the Autonomic Nervous System

The purpose of this information paper is to provide a general overview of the current evidence related to the impact of concussion, or mild traumatic brain injury, on the autonomic nervous system (ANS). This paper will focus on heart rate variability, pupillary light reflex, and hyperhidrosis within the military and civilian populations.

Thumbnail image of the downloadable Information Paper on the Impact of mTBI on the Autonomic Nervous SystemDownload this information paper to learn more about the state-of-the-science of how the autonomic nervous system is impacted by mild TBI. Researchers and clinicians can learn about current tools used to measure ANS and their current clinical utility at this time.

TBICoE Research Reviews

The following TBICoE research reviews are fluid areas of investigation and provide an overview on specific topics of interest related to TBI research. These reviews will be updated as new research emerges.

Multiple Traumatic Brain Injury/Multiple Concussion

Mild Traumatic Brain Injury and Posttraumatic Stress Disorder

Chronic Traumatic Encephalopathy

TBICoE Congressional Reporting

Many of TBICoE’s drivers include mandates from Congress within the National Defense Authorization Act (NDAA). In response to and in accordance with the requirements of these mandates, a number of reports have been submitted to Congress and are available in the public record.

NDAA FY20 Sec 750 Report to Congress: Study and Report on Traumatic Brain Injury Mitigation Efforts

A study and report on TBI mitigation efforts. This report summarizes the DOD’s findings that assessed 30 unique TBI treatments published between 2015 and 2020, and provides a roadmap addressing TBI mitigation efforts.

NDAA FY19 on Chronic Traumatic Encephalopathy

A study and report on Chronic Traumatic Encephalopathy (CTE) research in the military. This report summarizes key knowledge gaps between CTE and traumatic brain injury, and outlines CTE-relevant initiatives pursued through research collaborations across Government agencies, academia, and leading research institutions.

NDAA FY18 Sec 734 Report to Congress: Longitudinal Medical Study on Blast Pressure Exposure of Members of the Armed Forces

Longitudinal medical study on Blast Exposure Pressure of Members of the Armed Forces. The Section 734 Program is inclusive of the following mandates: NDAA FY18 Section 734, NDAA FY19 Section 253, NDAA FY20 Section 717, and NDAA FY20 Section 742.

NDAA FY07 Sec 721 Report to Congress: Longitudinal Study on Traumatic Brain Injury Incurred by Members of the Armed Forces in OIF/OEF

Fifteen-year longitudinal study on health effects related to TBI incurred by members of the Armed Forces in OIF/OEF and their families.

TBICoE Publications

Since 1992, TBICoE has published over 700 peer reviewed manuscripts in collaboration with other institutions, which actively align and respond to trends, gaps, and priorities of the Defense Health Agency or broader Department of Defense to inform policy, resource management, and state of the science for warfighters, veterans, their families and caregivers, and healthcare providers.

You also may be interested in...

Chronic Traumatic Encephalopathy (CTE) Frequently Asked Questions

Fact Sheet

This fact sheet provides answers and information to commonly asked questions about chronic traumatic encephalopathy, or CTE.

Recommended Content:

Traumatic Brain Injury Center of Excellence | TBICoE Research | TBI Provider Resources

Concussion/mTBI and PTSD Fact Sheet

Fact Sheet

This fact sheet defines concussion/mild traumatic brain injury and posttraumatic stress disorder and explains how overlapping symptoms often occur. It also describes why it’s important to seek out treatment for both conditions and provides helpful advice on what to tell your family and friends to help in the recovery process.

Recommended Content:

Traumatic Brain Injury Center of Excellence | Posttraumatic Stress Disorder | TBI Patient and Family Resources | TBICoE Research
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Last Updated: March 16, 2023
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