An understanding of the neuropathological and clinical presentation of chronic traumatic encephalopathy (CTE) is critical for determining if there are clinical and pathological stages of progression, relating pathology to clinical symptoms, identifying risk factors, and developing interventions to prevent onset or spread of symptoms and pathology. The purpose of this research review is to summarize the available peer-reviewed scientific literature regarding the definition, epidemiology, risk factors, pathology and clinical manifestations for CTE. A list of specific gaps in our understanding of the disease is provided that, if addressed, could inform the most appropriate prevention recommendations and allow clinicians to more effectively diagnose, manage and treat CTE.
