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Rotavirus Vaccine Resource Center


Rotavirus is the most common cause of severe gastroenteritis in infants and young children worldwide. Before initiation of the immunization program in 2006, nearly every child in the United States was infected with rotavirus by age 5 years. Severe dehydrating gastroenteritis caused by rotavirus occurred primarily among children aged 4-23 months. Rotavirus illness in children ranges from mild, watery diarrhea of limited duration to severe diarrhea with vomiting and fever than can result in dehydration with shock, electrolyte imbalance, and death.

There are two rotavirus vaccines licensed for use in the U.S. Both are administered orally; one is given in a 3-dose series at ages 2, 4, and 6 months, and the other in a 2-dose series at ages 2 and 4 months.

The minimum age for dose 1 of rotavirus vaccine is 6 weeks; the maximum age for dose 1 is 14 weeks and 6 days. Vaccination should not be initiated for infants aged 15 weeks and 0 days or older because of insufficient data on safety of dose 1 of rotavirus vaccine in older infants. The minimum interval between doses of rotavirus vaccine is 4 weeks. All doses should be administered by age 8 months and 0 days.

Source: Centers for Disease Control and Prevention

Resource Center

You will find below all of the resources you will need about the rotavirus vaccine. More will be added as they are published or released.

Information Paper Date
Rotavirus Disease and Rotavirus Vaccine Dec. 2, 2015
Standing Orders Date
Rotavirus Vaccine (Pediatric)
June 2022
Vaccine Information Statements (VIS) Date
Rotavirus Vaccine: What You Need to Know
Oct. 15, 2021
Manufacturer Package Inserts Date
Nov. 4, 2022
Aug. 14, 2020
Advisory Committee on Immunization Practices (ACIP) Recommendations Date
Rotavirus Vaccine
Oct. 21, 2011

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Trends in the Laboratory Detection of Rotavirus Before and After Implementation of Routine Rotavirus Vaccination — United States, 2000–2018


Implementation of the U.S. rotavirus vaccination program in 2006 reduced the annual proportion of positive rotavirus tests, reduced peak rotavirus activity, and shortened the duration of the rotavirus season.

Three Rotavirus Outbreaks in the Postvaccine Era — California, 2017


Rotavirus outbreaks in a child care center and an adult assisted living facility caused primarily mild illness. In a pediatric subacute care facility, illness was widespread and resulted in one death in a toddler with underlying complications. This report looks at the outbreaks and immunization status of those affected.

Rotavirus Disease and Rotavirus Vaccine

Fact Sheet

This information paper describes Rotavirus disease and vaccine to prevent it

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Last Updated: May 05, 2023
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